High basal heat-shock protein expression in bats confers resistance to cellular heat/oxidative stress

Bats, unique among mammals with powered flight, have many species with the longest size-proportionate lifespan of all mammals. Evolutionary adaptations would have been required to survive the elevated body temperatures during flight. Heat shock protein (HSP), highly conserved master regulators of ce...

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Bibliographic Details
Published in:Cell stress & chaperones 2019-07, Vol.24 (4), p.835-849
Main Authors: Chionh, Yok Teng, Cui, Jie, Koh, Javier, Mendenhall, Ian H., Ng, Justin H. J., Low, Dolyce, Itahana, Koji, Irving, Aaron T., Wang, Lin-Fa
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Physiological - physiology
Animals
Bats
Biochemistry
Biological evolution
Biomedical and Life Sciences
Biomedicine
Body temperature
Cancer Research
Cell Biology
Cell death
Cell Line
Cell lines
Chiroptera
Chiroptera - metabolism
Flight
Flight, Animal - physiology
Heat shock proteins
Heat treatment
Heat-Shock Response - physiology
HSP70 Heat-Shock Proteins - metabolism
Hsp70 protein
HSP90 Heat-Shock Proteins - metabolism
Hsp90 protein
Humans
Immunology
Life span
Longevity - physiology
Mammalian cells
Mammals
Neurosciences
Original Paper
Oxidation resistance
Oxidative stress
Oxidative Stress - physiology
Regulators
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Summary:Bats, unique among mammals with powered flight, have many species with the longest size-proportionate lifespan of all mammals. Evolutionary adaptations would have been required to survive the elevated body temperatures during flight. Heat shock protein (HSP), highly conserved master regulators of cell stress, expression was examined across tissues and various cell lines in bats. Basal expression level of major HSPs (HSP70 and HSP90) is significantly higher in two different bat species compared to other mammals. This HSP expression could be a bat-unique, key factor to modulate cellular stress and death. Consequently, bat cells survive prolonged heat treatment, along with other stress stimuli, in a HSP-dependent manner, whereas other mammalian cells succumbed. This suggests HSP expression in bats could be an important adaption to intrinsic metabolic stresses like flight and therefore an important model to study stress resilience and longevity in general.
ISSN:1355-8145
1466-1268
DOI:10.1007/s12192-019-01013-y