Vibrissa-Based Object Localization in Head-Fixed Mice

Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over...

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Bibliographic Details
Published in:The Journal of neuroscience 2010-02, Vol.30 (5), p.1947-1967
Main Authors: O'Connor, Daniel H, Clack, Nathan G, Huber, Daniel, Komiyama, Takaki, Myers, Eugene W, Svoboda, Karel
Format: Article
Language:English
Subjects:
Animals
Exploratory Behavior - physiology
Head Movements - physiology
Mice
Mice, Inbred C57BL
Movement - physiology
Restraint, Physical
Somatosensory Cortex - physiology
Somatosensory Cortex - physiopathology
Space Perception - physiology
Touch - physiology
Vibrissae - physiology
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Summary:Linking activity in specific cell types with perception, cognition, and action, requires quantitative behavioral experiments in genetic model systems such as the mouse. In head-fixed primates, the combination of precise stimulus control, monitoring of motor output, and physiological recordings over large numbers of trials are the foundation on which many conceptually rich and quantitative studies have been built. Choice-based, quantitative behavioral paradigms for head-fixed mice have not been described previously. Here, we report a somatosensory absolute object localization task for head-fixed mice. Mice actively used their mystacial vibrissae (whiskers) to sense the location of a vertical pole presented to one side of the head and reported with licking whether the pole was in a target (go) or a distracter (no-go) location. Mice performed hundreds of trials with high performance (>90% correct) and localized to
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.3762-09.2010