Association of rs4784227-CASC16 (LOC643714 locus) and rs4782447-ACSF3 polymorphisms and their association with breast cancer risk among Iranian population

TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. and , as single nucleotide polymorphisms (SNPs), located at the may affect the FOXA1 DNA binding sequence change and therefore may enhance the FOXA1-binding affinity to the promoter of gene. This study aimed...

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Published in:EXCLI journal 2019-01, Vol.18, p.429-438
Main Authors: Tajbakhsh, Amir, Farjami, Zahra, Darroudi, Susan, Ayati, Seyed Hasan, Vakili, Fatemeh, Asghari, Mahla, Alimardani, Maliheh, Abedini, Soheila, Kushyar, Mohammad Mahdi, Pasdar, Alireza
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Language:English
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Summary:TOX3 and FOXA1 proteins are believed to be involved in the susceptibility of breast cancer. and , as single nucleotide polymorphisms (SNPs), located at the may affect the FOXA1 DNA binding sequence change and therefore may enhance the FOXA1-binding affinity to the promoter of gene. This study aimed to investigate the association of these SNPs/haplotypes with breast cancer susceptibility in an Iranian population. We conducted a case-control study of 1072 blood samples (505 breast cancer patients and 567 controls). Genotyping of and SNPs was carried out by ARMS-PCR. Moreover, statistical analysis was done using SPSS version 20.0 (IBM Inc., Chicago, IL, USA), PHASE v 2.1 and SNP analyser 2.0. There was a strongly significant statistical association between alleles and genotypes of with breast cancer risk in our study population (p
ISSN:1611-2156
1611-2156
DOI:10.17179/excli2019-1374