p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis

BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell–extracellular matrix (ECM) adhesion and...

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Bibliographic Details
Published in:Gene 2015-05, Vol.562 (1), p.1-7
Main Authors: Camacho Leal, Maria del Pilar, Sciortino, Marianna, Tornillo, Giusy, Colombo, Shana, Defilippi, Paola, Cabodi, Sara
Format: Article
Language:English
Subjects:
Adaptor protein
Animals
biological models
Cancer
Cell Adhesion
Cell motility
Cell Movement
Crk-Associated Substrate Protein - genetics
Crk-Associated Substrate Protein - metabolism
Development
Drosophila melanogaster - genetics
Drosophila melanogaster - growth & development
Drosophila melanogaster - metabolism
Extracellular Matrix
Gene Expression Regulation
Homeostasis
Humans
Intracellular signaling pathways
Mechanotransduction, Cellular
Mice
Morphogenesis - genetics
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Organ Specificity
p130Cas/BCAR1
pathogenesis
Phosphorylation
Protein Structure, Tertiary
scaffolding proteins
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Summary:BCAR1 (also known as p130Cas/BCAR1) is an adaptor protein that belongs to the CAS family of scaffold proteins. In the past years, increasing evidence has demonstrated the ability of p130Cas/BCAR1 to activate signaling originating from mechanical stimuli, cell–extracellular matrix (ECM) adhesion and growth factor stimulation cascades during normal development and disease in various biological models. In this review we will specifically discuss the more recent data on the contribution of p130Cas/BCAR1 in the regulation of tissue homeostasis and its potential implications in pathological conditions.
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2015.02.027