Loading…
Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction
Introduction Exercise-based cardiac rehabilitation (EBCR) is part of the management of patients who have suffered an acute myocardial infarction (AMI). Patients with a reduced ejection fraction (EF) comprise a higher-risk subgroup and are referred less often for these programmes. This study aimed at...
Saved in:
Published in: | Netherlands heart journal 2019-07, Vol.27 (7-8), p.347-353 |
---|---|
Main Authors: | , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03 |
---|---|
cites | cdi_FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03 |
container_end_page | 353 |
container_issue | 7-8 |
container_start_page | 347 |
container_title | Netherlands heart journal |
container_volume | 27 |
creator | Vilela, E. M. Ladeiras-Lopes, R. Ruivo, C. Torres, S. Braga, J. Fonseca, M. Ribeiro, J. Primo, J. Fontes-Carvalho, R. Campos, L. Miranda, F. Nunes, J. P. L. Gama, V. Teixeira, M. Braga, P. |
description | Introduction
Exercise-based cardiac rehabilitation (EBCR) is part of the management of patients who have suffered an acute myocardial infarction (AMI). Patients with a reduced ejection fraction (EF) comprise a higher-risk subgroup and are referred less often for these programmes. This study aimed at assessing the impact of the baseline EF on the functional benefits, as assessed by peak oxygen uptake (pVO
2
) and exercise duration, of an EBCR programme in AMI survivors.
Methods
Observational, retrospective cohort study including all patients admitted to a tertiary centre due to an AMI who completed a phase II EBCR programme after discharge, between November 2012 and April 2017. Functional parameters were assessed by a symptom-limited cardiopulmonary exercise test.
Results
A total of 379 patients were included [40.9% with reduced EF ( |
doi_str_mv | 10.1007/s12471-019-1269-7 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6639836</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2209604736</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03</originalsourceid><addsrcrecordid>eNp1kc1u1DAUhSNERUvhAdggS2y6Cb12HP9skFD5lSqxgbXlca6nHiXxYCcj9Um65Vn6ZHgmpbRIrHx1z3eP7Xuq6hWFtxRAnmfKuKQ1UF1TJnQtn1QnVElRC9bC01K3QtWtUuq4ep7zBqCVjMpn1XEDWkrgcFLdfAjeY8JxInGeXBwwk-iJvf3lbOqCdSThlV2FPkx2CnEk2xTXyQ4DkjASP49u37U92drSxQlTJnaI45oM13Gx6AvpbTqAJM9pF3ZxTzkXi1zIKRLc4KL7ZA_Fi-rI2z7jy7vztPrx6eP3iy_15bfPXy_eX9aOS5hqqX2rtVSeWy6Ed0x4BYCrTq2Qg-9URwGx0a1THdNCMmy6zjIUDeWt7qA5rd4tvtt5NWDnyiKS7c02hcGmaxNtMI-VMVyZddwZIRqtGlEMzu4MUvw5Y57MELLDvrcjxjkbxkAL4PKAvvkH3cQ5leUVSjLdcqCNKhRdKJdizgn9_WMomH3sZondlNjNPnYjy8zrh7-4n_iTcwHYAuQijWtMf6_-v-tvAAa-UA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2729540138</pqid></control><display><type>article</type><title>Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction</title><source>Publicly Available Content Database</source><source>Springer Nature - SpringerLink Journals - Fully Open Access </source><source>PubMed Central</source><creator>Vilela, E. M. ; Ladeiras-Lopes, R. ; Ruivo, C. ; Torres, S. ; Braga, J. ; Fonseca, M. ; Ribeiro, J. ; Primo, J. ; Fontes-Carvalho, R. ; Campos, L. ; Miranda, F. ; Nunes, J. P. L. ; Gama, V. ; Teixeira, M. ; Braga, P.</creator><creatorcontrib>Vilela, E. M. ; Ladeiras-Lopes, R. ; Ruivo, C. ; Torres, S. ; Braga, J. ; Fonseca, M. ; Ribeiro, J. ; Primo, J. ; Fontes-Carvalho, R. ; Campos, L. ; Miranda, F. ; Nunes, J. P. L. ; Gama, V. ; Teixeira, M. ; Braga, P.</creatorcontrib><description>Introduction
Exercise-based cardiac rehabilitation (EBCR) is part of the management of patients who have suffered an acute myocardial infarction (AMI). Patients with a reduced ejection fraction (EF) comprise a higher-risk subgroup and are referred less often for these programmes. This study aimed at assessing the impact of the baseline EF on the functional benefits, as assessed by peak oxygen uptake (pVO
2
) and exercise duration, of an EBCR programme in AMI survivors.
Methods
Observational, retrospective cohort study including all patients admitted to a tertiary centre due to an AMI who completed a phase II EBCR programme after discharge, between November 2012 and April 2017. Functional parameters were assessed by a symptom-limited cardiopulmonary exercise test.
Results
A total of 379 patients were included [40.9% with reduced EF (<50%) at discharge]. After the programme, pVO
2
and exercise duration increased significantly (
p
< 0.001). Patients with a reduced EF had a lower pVO
2
and completed a shorter duration of exercise at the beginning and end of the programme. This group presented a higher increase in pVO
2
(
p
= 0.001) and exercise duration (
p
= 0.007). This was maintained after adjusting for age, gender, history of coronary artery disease, number of sessions, Killip classification, arterial hypertension, dyslipidaemia, diabetes mellitus, smoking status and baseline pVO
2
.
Conclusion
A phase II EBCR programme was associated with significant improvements in pVO
2
and exercise duration among AMI survivors, irrespective of baseline EF classification. Those with a reduced baseline EF derived an even greater improvement, highlighting the importance of EBCR in this subgroup of patients.</description><identifier>ISSN: 1568-5888</identifier><identifier>EISSN: 1876-6250</identifier><identifier>DOI: 10.1007/s12471-019-1269-7</identifier><identifier>PMID: 30977040</identifier><language>eng</language><publisher>Houten: Bohn Stafleu van Loghum</publisher><subject>Beta blockers ; Cardiology ; Cardiovascular disease ; Classification ; Coronary vessels ; Diabetes ; Ejection fraction ; Exercise ; Heart attacks ; Hospitals ; Hypertension ; Insulin ; Medical Education ; Medicine ; Medicine & Public Health ; Original ; Original Article ; Physical fitness ; Rehabilitation ; Statistical analysis ; Strength training ; Vein & artery diseases</subject><ispartof>Netherlands heart journal, 2019-07, Vol.27 (7-8), p.347-353</ispartof><rights>The Author(s) 2019</rights><rights>The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03</citedby><cites>FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2729540138/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2729540138?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,25731,27901,27902,36989,36990,44566,53766,53768,74869</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30977040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vilela, E. M.</creatorcontrib><creatorcontrib>Ladeiras-Lopes, R.</creatorcontrib><creatorcontrib>Ruivo, C.</creatorcontrib><creatorcontrib>Torres, S.</creatorcontrib><creatorcontrib>Braga, J.</creatorcontrib><creatorcontrib>Fonseca, M.</creatorcontrib><creatorcontrib>Ribeiro, J.</creatorcontrib><creatorcontrib>Primo, J.</creatorcontrib><creatorcontrib>Fontes-Carvalho, R.</creatorcontrib><creatorcontrib>Campos, L.</creatorcontrib><creatorcontrib>Miranda, F.</creatorcontrib><creatorcontrib>Nunes, J. P. L.</creatorcontrib><creatorcontrib>Gama, V.</creatorcontrib><creatorcontrib>Teixeira, M.</creatorcontrib><creatorcontrib>Braga, P.</creatorcontrib><title>Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction</title><title>Netherlands heart journal</title><addtitle>Neth Heart J</addtitle><addtitle>Neth Heart J</addtitle><description>Introduction
Exercise-based cardiac rehabilitation (EBCR) is part of the management of patients who have suffered an acute myocardial infarction (AMI). Patients with a reduced ejection fraction (EF) comprise a higher-risk subgroup and are referred less often for these programmes. This study aimed at assessing the impact of the baseline EF on the functional benefits, as assessed by peak oxygen uptake (pVO
2
) and exercise duration, of an EBCR programme in AMI survivors.
Methods
Observational, retrospective cohort study including all patients admitted to a tertiary centre due to an AMI who completed a phase II EBCR programme after discharge, between November 2012 and April 2017. Functional parameters were assessed by a symptom-limited cardiopulmonary exercise test.
Results
A total of 379 patients were included [40.9% with reduced EF (<50%) at discharge]. After the programme, pVO
2
and exercise duration increased significantly (
p
< 0.001). Patients with a reduced EF had a lower pVO
2
and completed a shorter duration of exercise at the beginning and end of the programme. This group presented a higher increase in pVO
2
(
p
= 0.001) and exercise duration (
p
= 0.007). This was maintained after adjusting for age, gender, history of coronary artery disease, number of sessions, Killip classification, arterial hypertension, dyslipidaemia, diabetes mellitus, smoking status and baseline pVO
2
.
Conclusion
A phase II EBCR programme was associated with significant improvements in pVO
2
and exercise duration among AMI survivors, irrespective of baseline EF classification. Those with a reduced baseline EF derived an even greater improvement, highlighting the importance of EBCR in this subgroup of patients.</description><subject>Beta blockers</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Classification</subject><subject>Coronary vessels</subject><subject>Diabetes</subject><subject>Ejection fraction</subject><subject>Exercise</subject><subject>Heart attacks</subject><subject>Hospitals</subject><subject>Hypertension</subject><subject>Insulin</subject><subject>Medical Education</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Article</subject><subject>Physical fitness</subject><subject>Rehabilitation</subject><subject>Statistical analysis</subject><subject>Strength training</subject><subject>Vein & artery diseases</subject><issn>1568-5888</issn><issn>1876-6250</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp1kc1u1DAUhSNERUvhAdggS2y6Cb12HP9skFD5lSqxgbXlca6nHiXxYCcj9Um65Vn6ZHgmpbRIrHx1z3eP7Xuq6hWFtxRAnmfKuKQ1UF1TJnQtn1QnVElRC9bC01K3QtWtUuq4ep7zBqCVjMpn1XEDWkrgcFLdfAjeY8JxInGeXBwwk-iJvf3lbOqCdSThlV2FPkx2CnEk2xTXyQ4DkjASP49u37U92drSxQlTJnaI45oM13Gx6AvpbTqAJM9pF3ZxTzkXi1zIKRLc4KL7ZA_Fi-rI2z7jy7vztPrx6eP3iy_15bfPXy_eX9aOS5hqqX2rtVSeWy6Ed0x4BYCrTq2Qg-9URwGx0a1THdNCMmy6zjIUDeWt7qA5rd4tvtt5NWDnyiKS7c02hcGmaxNtMI-VMVyZddwZIRqtGlEMzu4MUvw5Y57MELLDvrcjxjkbxkAL4PKAvvkH3cQ5leUVSjLdcqCNKhRdKJdizgn9_WMomH3sZondlNjNPnYjy8zrh7-4n_iTcwHYAuQijWtMf6_-v-tvAAa-UA</recordid><startdate>20190701</startdate><enddate>20190701</enddate><creator>Vilela, E. M.</creator><creator>Ladeiras-Lopes, R.</creator><creator>Ruivo, C.</creator><creator>Torres, S.</creator><creator>Braga, J.</creator><creator>Fonseca, M.</creator><creator>Ribeiro, J.</creator><creator>Primo, J.</creator><creator>Fontes-Carvalho, R.</creator><creator>Campos, L.</creator><creator>Miranda, F.</creator><creator>Nunes, J. P. L.</creator><creator>Gama, V.</creator><creator>Teixeira, M.</creator><creator>Braga, P.</creator><general>Bohn Stafleu van Loghum</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20190701</creationdate><title>Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction</title><author>Vilela, E. M. ; Ladeiras-Lopes, R. ; Ruivo, C. ; Torres, S. ; Braga, J. ; Fonseca, M. ; Ribeiro, J. ; Primo, J. ; Fontes-Carvalho, R. ; Campos, L. ; Miranda, F. ; Nunes, J. P. L. ; Gama, V. ; Teixeira, M. ; Braga, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Beta blockers</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Classification</topic><topic>Coronary vessels</topic><topic>Diabetes</topic><topic>Ejection fraction</topic><topic>Exercise</topic><topic>Heart attacks</topic><topic>Hospitals</topic><topic>Hypertension</topic><topic>Insulin</topic><topic>Medical Education</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Article</topic><topic>Physical fitness</topic><topic>Rehabilitation</topic><topic>Statistical analysis</topic><topic>Strength training</topic><topic>Vein & artery diseases</topic><toplevel>online_resources</toplevel><creatorcontrib>Vilela, E. M.</creatorcontrib><creatorcontrib>Ladeiras-Lopes, R.</creatorcontrib><creatorcontrib>Ruivo, C.</creatorcontrib><creatorcontrib>Torres, S.</creatorcontrib><creatorcontrib>Braga, J.</creatorcontrib><creatorcontrib>Fonseca, M.</creatorcontrib><creatorcontrib>Ribeiro, J.</creatorcontrib><creatorcontrib>Primo, J.</creatorcontrib><creatorcontrib>Fontes-Carvalho, R.</creatorcontrib><creatorcontrib>Campos, L.</creatorcontrib><creatorcontrib>Miranda, F.</creatorcontrib><creatorcontrib>Nunes, J. P. L.</creatorcontrib><creatorcontrib>Gama, V.</creatorcontrib><creatorcontrib>Teixeira, M.</creatorcontrib><creatorcontrib>Braga, P.</creatorcontrib><collection>Springer Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Netherlands heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vilela, E. M.</au><au>Ladeiras-Lopes, R.</au><au>Ruivo, C.</au><au>Torres, S.</au><au>Braga, J.</au><au>Fonseca, M.</au><au>Ribeiro, J.</au><au>Primo, J.</au><au>Fontes-Carvalho, R.</au><au>Campos, L.</au><au>Miranda, F.</au><au>Nunes, J. P. L.</au><au>Gama, V.</au><au>Teixeira, M.</au><au>Braga, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction</atitle><jtitle>Netherlands heart journal</jtitle><stitle>Neth Heart J</stitle><addtitle>Neth Heart J</addtitle><date>2019-07-01</date><risdate>2019</risdate><volume>27</volume><issue>7-8</issue><spage>347</spage><epage>353</epage><pages>347-353</pages><issn>1568-5888</issn><eissn>1876-6250</eissn><abstract>Introduction
Exercise-based cardiac rehabilitation (EBCR) is part of the management of patients who have suffered an acute myocardial infarction (AMI). Patients with a reduced ejection fraction (EF) comprise a higher-risk subgroup and are referred less often for these programmes. This study aimed at assessing the impact of the baseline EF on the functional benefits, as assessed by peak oxygen uptake (pVO
2
) and exercise duration, of an EBCR programme in AMI survivors.
Methods
Observational, retrospective cohort study including all patients admitted to a tertiary centre due to an AMI who completed a phase II EBCR programme after discharge, between November 2012 and April 2017. Functional parameters were assessed by a symptom-limited cardiopulmonary exercise test.
Results
A total of 379 patients were included [40.9% with reduced EF (<50%) at discharge]. After the programme, pVO
2
and exercise duration increased significantly (
p
< 0.001). Patients with a reduced EF had a lower pVO
2
and completed a shorter duration of exercise at the beginning and end of the programme. This group presented a higher increase in pVO
2
(
p
= 0.001) and exercise duration (
p
= 0.007). This was maintained after adjusting for age, gender, history of coronary artery disease, number of sessions, Killip classification, arterial hypertension, dyslipidaemia, diabetes mellitus, smoking status and baseline pVO
2
.
Conclusion
A phase II EBCR programme was associated with significant improvements in pVO
2
and exercise duration among AMI survivors, irrespective of baseline EF classification. Those with a reduced baseline EF derived an even greater improvement, highlighting the importance of EBCR in this subgroup of patients.</abstract><cop>Houten</cop><pub>Bohn Stafleu van Loghum</pub><pmid>30977040</pmid><doi>10.1007/s12471-019-1269-7</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1568-5888 |
ispartof | Netherlands heart journal, 2019-07, Vol.27 (7-8), p.347-353 |
issn | 1568-5888 1876-6250 |
language | eng |
recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6639836 |
source | Publicly Available Content Database; Springer Nature - SpringerLink Journals - Fully Open Access ; PubMed Central |
subjects | Beta blockers Cardiology Cardiovascular disease Classification Coronary vessels Diabetes Ejection fraction Exercise Heart attacks Hospitals Hypertension Insulin Medical Education Medicine Medicine & Public Health Original Original Article Physical fitness Rehabilitation Statistical analysis Strength training Vein & artery diseases |
title | Different outcomes of a cardiac rehabilitation programme in functional parameters among myocardial infarction survivors according to ejection fraction |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T01%3A44%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Different%20outcomes%20of%20a%C2%A0cardiac%20rehabilitation%20programme%20in%20functional%20parameters%20among%20myocardial%20infarction%20survivors%20according%20to%20ejection%20fraction&rft.jtitle=Netherlands%20heart%20journal&rft.au=Vilela,%20E.%20M.&rft.date=2019-07-01&rft.volume=27&rft.issue=7-8&rft.spage=347&rft.epage=353&rft.pages=347-353&rft.issn=1568-5888&rft.eissn=1876-6250&rft_id=info:doi/10.1007/s12471-019-1269-7&rft_dat=%3Cproquest_pubme%3E2209604736%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c470t-79f59978f4a466fc26f800ebd8be40fd8d10ee395c8d29672e3dda2e631459d03%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2729540138&rft_id=info:pmid/30977040&rfr_iscdi=true |