Synthesis and direct comparison of the anticancer activities of phomopsolides D and E and two 7-oxa-/7-aza-analogues† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9md00121b

The synthesis and biological evaluation of two phomopsolide natural products (D and E) and two analogues is presented. The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a pan...

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Bibliographic Details
Published in:MedChemComm 2019-05, Vol.10 (7), p.1205-1211
Main Authors: Aljahdali, Alhanouf Z., Freedman, Seth A., Scott, Jana, Li, Miaosheng, O'Doherty, George A.
Format: Article
Language:English
Subjects:
Chemistry
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Summary:The synthesis and biological evaluation of two phomopsolide natural products (D and E) and two analogues is presented. The synthesis of two stable phomopsolide natural products (D and E) and two analogues is presented. The cytotoxicities of these four compounds are surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2–50 μM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.
ISSN:2040-2503
2040-2511
DOI:10.1039/c9md00121b