Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors

In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in...

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Published in:Contrast media and molecular imaging 2019, Vol.2019 (2019), p.1-18
Main Authors: Zhou, Guofu, Feng, Shi-Ting, Wang, Yao, Li, Yong-Rui, Gan, Sheng-Long, Lin, Yi-Sheng, Fu, Jia-Wei, Li, Hao
Format: Article
Language:English
Subjects:
Acoustic impedance
Biomedical materials
Blood
Bubbles
Cancer therapies
Containment
Contrast agents
Contrast Media
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Erythrocytes
Graphene
Humans
Imaging techniques
Microbubbles - therapeutic use
Nanoparticles
Neoplasms - diagnosis
Neoplasms - therapy
NMR
Nuclear magnetic resonance
Precision medicine
Review
Theranostic Nanomedicine - methods
Tumors
Ultrasonic imaging
Ultrasonography - methods
Ultrasound
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container_issue 2019
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container_title Contrast media and molecular imaging
container_volume 2019
creator Zhou, Guofu
Feng, Shi-Ting
Wang, Yao
Li, Yong-Rui
Gan, Sheng-Long
Lin, Yi-Sheng
Fu, Jia-Wei
Li, Hao
description In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most common UCA, microbubble, is generally close in size to a red blood cell (
doi_str_mv 10.1155/2019/3145647
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Typically, the most common UCA, microbubble, is generally close in size to a red blood cell (&lt;∼10 μm). These microscale UCAs cannot be directly entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. And their large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.</description><identifier>ISSN: 1555-4309</identifier><identifier>EISSN: 1555-4317</identifier><identifier>DOI: 10.1155/2019/3145647</identifier><identifier>PMID: 31360144</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Acoustic impedance ; Biomedical materials ; Blood ; Bubbles ; Cancer therapies ; Containment ; Contrast agents ; Contrast Media ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Erythrocytes ; Graphene ; Humans ; Imaging techniques ; Microbubbles - therapeutic use ; Nanoparticles ; Neoplasms - diagnosis ; Neoplasms - therapy ; NMR ; Nuclear magnetic resonance ; Precision medicine ; Review ; Theranostic Nanomedicine - methods ; Tumors ; Ultrasonic imaging ; Ultrasonography - methods ; Ultrasound</subject><ispartof>Contrast media and molecular imaging, 2019, Vol.2019 (2019), p.1-18</ispartof><rights>Copyright © 2019 Jia-Wei Fu et al.</rights><rights>Copyright © 2019 Jia-Wei Fu et al. 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subjects Acoustic impedance
Biomedical materials
Blood
Bubbles
Cancer therapies
Containment
Contrast agents
Contrast Media
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Erythrocytes
Graphene
Humans
Imaging techniques
Microbubbles - therapeutic use
Nanoparticles
Neoplasms - diagnosis
Neoplasms - therapy
NMR
Nuclear magnetic resonance
Precision medicine
Review
Theranostic Nanomedicine - methods
Tumors
Ultrasonic imaging
Ultrasonography - methods
Ultrasound
title Multifunctionalized Microscale Ultrasound Contrast Agents for Precise Theranostics of Malignant Tumors
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