Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer

Metabolic disorders can lead to a scarcity or excess of certain metabolites such as glucose, lipids, proteins, purines, and metal ions, which provide the biochemical foundation and directly contribute to the etiology of metabolic diseases. Nonalcoholic fatty liver disease, obesity, and cancer are co...

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Bibliographic Details
Published in:International journal of biological sciences 2019-01, Vol.15 (8), p.1654-1663
Main Authors: Cheng, Can, Zhuo, Songming, Zhang, Bo, Zhao, Xu, Liu, Ying, Liao, Chaoliang, Quan, Jing, Li, Zhenzhen, Bode, Ann M, Cao, Ya, Luo, Xiangjian
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Cancer
Chemical compounds
Deregulation
Disorders
Etiology
Fatty liver
Flavonoids
Humans
Lipid metabolism
Lipid Metabolism - genetics
Lipid Metabolism - physiology
Lipids
Liver
Liver cancer
Liver diseases
Metabolic disorders
Metabolites
Metal ions
Natural products
Neoplasms - immunology
Neoplasms - metabolism
Non-alcoholic Fatty Liver Disease - immunology
Non-alcoholic Fatty Liver Disease - metabolism
Obesity
Obesity - immunology
Obesity - metabolism
Pharmacology
Purines
Review
Terpenes
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Summary:Metabolic disorders can lead to a scarcity or excess of certain metabolites such as glucose, lipids, proteins, purines, and metal ions, which provide the biochemical foundation and directly contribute to the etiology of metabolic diseases. Nonalcoholic fatty liver disease, obesity, and cancer are common metabolic disorders closely associated with abnormal lipid metabolism. In this review, we first describe the regulatory machinery of lipid metabolism and its deregulation in metabolic diseases. Next, we enumerate and integrate the mechanism of action of some natural compounds, including terpenoids and flavonoids, to ameliorate the development of metabolic diseases by targeting lipid metabolism. Medicinal natural products have an established history of use in health care and therapy. Natural compounds might provide a good source of potential therapeutic agents for treating or preventing metabolic diseases with lipid metabolic abnormalities.
ISSN:1449-2288
1449-2288
DOI:10.7150/ijbs.33837