Comparison of Serum Ykl-40 and Ischemia Modified Albulmin Levels Between Pregnant Women with Hyperemesis Gravidarum and Normal Pregnant Women

Introduction: The etiopathogenesis of HG is still unclear. Aim: The aim of this study was to investigate the levels of YKL-40 protein as an inflammatory marker and evaluate the levels of IMA as an oxidative marker in hyperemesis gravidarum women. Materials and Methods: Totally 35 patients with hyper...

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Bibliographic Details
Published in:Medicinski arhiv 2019-04, Vol.73 (2), p.97-100
Main Authors: Bulanik, Murat, Sagsoz, Nevin, Sayan, Cemile Dayangan, Mahmut Ilkin Yeral, Ucler Kisa
Format: Article
Language:English
Subjects:
Biomarkers
Etiology
Inflammation
Ischemia
Nausea
Original Paper
Oxidative stress
Pathology
Pregnancy
Proteins
Vomiting
Womens health
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Summary:Introduction: The etiopathogenesis of HG is still unclear. Aim: The aim of this study was to investigate the levels of YKL-40 protein as an inflammatory marker and evaluate the levels of IMA as an oxidative marker in hyperemesis gravidarum women. Materials and Methods: Totally 35 patients with hyperemesis gravidarum and 35 healthy pregnants were included in the study. Singleton pregnancies between 6+0 week and 13+6 weeks of gestation, with normal fetal anatomy were included in the study. Complete blood count, complete urine analyze, biochemical tests and thyroid function tests were done. Results: There was no significant difference between groups for demographical features (age, gravidity, gestational age, body mass index). Also, there was no statistically significant difference between groups for IMA levels (p>0.05). The median level of YKL-40 was higher in pregnants with hyperemesis gravidarum than normal pregnants but the difference was not statistically significance (p>0.05). Conclusion: Further comprehensive studies with more number of patients are needed to show the efficacy of YKL-40 and IMA levels for predicting hyperemesis gravidarum and even monitoring of the treatment.
ISSN:0350-199X
1986-5961
DOI:10.5455/medarh.2019.73.97-100