The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

TObjectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm);...

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Bibliographic Details
Published in:Turkish journal of physical medicine and rehabilitation 2017-06, Vol.63 (2), p.165-173
Main Authors: Tokmak Özşahin, Esin Tokmak, Çam, Burcu, Dere, Fahri, Kürkçü, Mehmet, Evrüke, Cüneyt, Soames, Roger, Oğuz, Özkan
Format: Article
Language:English
Subjects:
Alendronate
Health aspects
Original
Physiological aspects
Trabecular bone
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Summary:TObjectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days. Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p
ISSN:2587-0823
1302-0234
2587-0823
DOI:10.5606/tftrd.2017.164