The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model

TObjectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm);...

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Published in:Turkish journal of physical medicine and rehabilitation 2017-06, Vol.63 (2), p.165-173
Main Authors: Tokmak Özşahin, Esin Tokmak, Çam, Burcu, Dere, Fahri, Kürkçü, Mehmet, Evrüke, Cüneyt, Soames, Roger, Oğuz, Özkan
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Language:English
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Alendronate
Health aspects
Original
Physiological aspects
Trabecular bone
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container_issue 2
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container_title Turkish journal of physical medicine and rehabilitation
container_volume 63
creator Tokmak Özşahin, Esin Tokmak
Çam, Burcu
Dere, Fahri
Kürkçü, Mehmet
Evrüke, Cüneyt
Soames, Roger
Oğuz, Özkan
description TObjectives: This study aims to investigate the effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model. Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days. Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p
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Between May 2006 and July 2006, 60 female Wistar Albino rats aged three months were randomly allocated to three groups: sham operated receiving no treatment (Shm); ovariectomized-alendronate receiving 1 mg/kg/day alendronate sodium (Ovx-A), and ovariectomized-vehicle receiving 1 mL/kg/day physiological saline (Ovx-PS). Both Ovx groups received treatment through gastric gavage for 56 days. Densitometric measurements showed that bone mineral density decreased in the Ovx-PS and increased in Ovx-A groups (p&lt;0.05). Biomechanical measurements showed a decrease in the breaking force in the Ovx-PS group and an increase in the Ovx-A group (p&lt;0.05). Histomorphometric measurements showed that the Shm group had normal trabecular structure, while the Ovx-PS group had a less well- formed trabecular structure with a loss in the trabecular number and thickness and a corresponding increase in the trabecular spacing (p&lt;0.05). 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subjects Alendronate
Health aspects
Original
Physiological aspects
Trabecular bone
title The effect of alendronate sodium on trabecular bone structure in an osteoporotic rat model
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