Retrospective single-centre analysis of IgG4-related disease patient population and treatment outcomes between 2007 and 2017

Abstract Objective The aim was to gain a better understanding of the prevalence, organ involvement, clinical characteristics and long-term outcomes of medical and surgical treatments of IgG4-related disease (IgG4-RD). Methods Query of the Cleveland Clinic pathology database for IgG4 plasma cell stai...

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Bibliographic Details
Published in:Rheumatology advances in practice 2019-01, Vol.3 (1), p.rkz014-rkz014
Main Authors: Lee, Chan Mi, Alalwani, Mohamed, Prayson, Richard A, Gota, Carmen E
Format: Article
Language:English
Subjects:
Care and treatment
Diseases
Glucocorticoids
Immunoglobulin G
Immunologic deficiency syndromes
Medical records
Medical research
Original
Patient outcomes
Power (Philosophy)
Prednisone
Surgery
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Summary:Abstract Objective The aim was to gain a better understanding of the prevalence, organ involvement, clinical characteristics and long-term outcomes of medical and surgical treatments of IgG4-related disease (IgG4-RD). Methods Query of the Cleveland Clinic pathology database for IgG4 plasma cell staining between 2007 and 2017 yielded 1481 results, of which 57 cases were identified as highly likely (n = 28; 49%) or probable (n = 29; 51%) IgG4-RD by histopathological criteria and IgG4 serum concentrations. Patient demographics, type of treatment and outcomes were retrieved from medical records. Patients were designated as being in remission if indicated in the chart and/or symptom- and objective finding-free for >6 months, relapsed if symptoms/findings recurred after remission, active if no remission was achieved during follow-up, and as unable to determine if the duration of follow-up was 40%. In our cohort, surgical treatment compared with medical treatment had a higher proportion of remission according to our outcome classification.
ISSN:2514-1775
2514-1775
DOI:10.1093/rap/rkz014