The Clinical Significance of Aspirin Resistance in Patients With Chest Pain

Background There are conflicting data in the literature about the clinical significance of aspirin resistance. Hypothesis We aimed to prospectively evaluate the prevalence of biochemical aspirin resistance in patients on aspirin therapy who were admitted to the emergency clinic with chest pain. We a...

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Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2010-03, Vol.33 (3), p.E1-E7
Main Authors: Aydinalp, Alp, Atar, Ilyas, Gulmez, Oyku, Atar, Asli, Acikel, Sadik, Bozbas, Huseyin, Ozgul, Aliseydi, Ertan, Cagatay, Ozin, Bulent, Muderrisoglu, Haldun
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome
Aged
Analysis of Variance
Aspirin - pharmacology
Biomarkers, Pharmacological
Blood Platelets - drug effects
Chest Pain
Clinical Investigation
Clinical Investigations
Collagen - drug effects
Confidence Intervals
Cross-Sectional Studies
Drug Resistance - drug effects
Epinephrine
Female
Humans
Logistic Models
Male
Middle Aged
Multivariate Analysis
Odds Ratio
Platelet Aggregation Inhibitors - pharmacology
Platelet Count
Prevalence
Prospective Studies
Risk Factors
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Summary:Background There are conflicting data in the literature about the clinical significance of aspirin resistance. Hypothesis We aimed to prospectively evaluate the prevalence of biochemical aspirin resistance in patients on aspirin therapy who were admitted to the emergency clinic with chest pain. We also aimed to evaluate the relation between acute coronary syndromes (ACS) and aspirin resistance. Methods A total of 338 patients were included in the study. Platelet reactivity was measured with the PFA‐100 system (Dade Behring Inc, Deerfield, IL). Aspirin resistance determined by the PFA‐100 was defined as a normal collagen and/or epinephrine closure time despite aspirin treatment (
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.20539