Effect of local aromatase inhibition in endometriosis using a new chick embryo chorioallantoic membrane model

Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibi...

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Bibliographic Details
Published in:Journal of cellular and molecular medicine 2019-08, Vol.23 (8), p.5808-5812
Main Authors: Pluchino, Nicola, Poppi, Giorgia, Yart, Lucile, Marci, Roberto, Wenger, Jean‐Marie, Tille, Jean‐Christophe, Cohen, Marie
Format: Article
Language:English
Subjects:
Anastrozole
Anastrozole - pharmacology
Anastrozole - therapeutic use
Animals
Aromatase
Aromatase Inhibitors - pharmacology
Aromatase Inhibitors - therapeutic use
Biology
Biopsy
Biosynthesis
Cell Proliferation - drug effects
Chick Embryo
chick embryo chorioallantoic membrane
Chorioallantoic membrane
Chorioallantoic Membrane - drug effects
Chorioallantoic Membrane - embryology
Chorioallantoic Membrane - pathology
Cysts
Deoxyribonucleic acid
Disease Models, Animal
DNA
Drug delivery
Drug screening
Embryos
Endometriosis
Endometriosis - drug therapy
Estrogens
Female
Humans
Metabolism
Ovaries
Ribosomal DNA
Short Communication
Short Communications
Side effects
Software
Statistical analysis
Testosterone
Transplants & implants
Xenografts
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Summary:Endometriosis is an oestrogen‐dependent, inflammation‐driven gynaecologic disorder causing severe disability. Endometriosis implants are characterized by unbalanced local oestrogen metabolism leading to hyperoestrogenism and aromatase up‐regulation is one of main mechanism involved. Aromatase inhibitors such as letrozole or anastrozole use in young women are associated with severely side effects limiting their long‐term clinical use. An endometriosis‐targeted inhibition of local aromatase could be a viable alternative, although the role of the local inhibition of this enzyme is still unclear. Using a new chick embryo allantoic membrane (CAM) model incorporating xenografted human endometriosis cyst, we showed that topical treatment with anastrozole reduced lesion size, although oestrogens produced by CAM female embryo blunted this effect. Xenografted human endometriosis CAM is a new efficient model for the screening of new drugs targeting endometriosis tissue.
ISSN:1582-1838
1582-4934
DOI:10.1111/jcmm.14372