Increased platelet activation and endothelial dysfunction in patients with atrial fibrillation immediately following percutaneous balloon mitral valvuloplasty

Background: Immediately following percutaneous balloon mitral valvuloplasty (PBMVP), patients have a 3% risk of systemic thromboembolism. Hypothesis: We hypothesized that this may in part be due to an increase in hypercoagulability (as indicated by abnormal coagulation, platelet activation, and endo...

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Published in:Clinical cardiology (Mahwah, N.J.) N.J.), 2000-08, Vol.23 (8), p.587-590
Main Authors: Goldsmith, Ira R.A., Li‐Saw‐Hee, Foo Leong, Blann, Andrew D., Lip, Gregory Y.H.
Format: Article
Language:English
Subjects:
atrial fibrillation
Atrial Fibrillation - complications
Biological and medical sciences
Catheterization - adverse effects
Chronic Disease
Diseases of the cardiovascular system
endothelial dysfunction
Endothelium, Vascular - physiopathology
Female
fibrinogen
Fibrinogen - analysis
Humans
Male
Medical sciences
Middle Aged
mitral valve
Mitral Valve Stenosis - complications
Mitral Valve Stenosis - surgery
P-Selectin - blood
Platelet Activation
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
valvuloplasty
von Willebrand factor
von Willebrand Factor - analysis
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Summary:Background: Immediately following percutaneous balloon mitral valvuloplasty (PBMVP), patients have a 3% risk of systemic thromboembolism. Hypothesis: We hypothesized that this may in part be due to an increase in hypercoagulability (as indicated by abnormal coagulation, platelet activation, and endothelial dysfunction) in such patients. Methods: We measured indices of platelet activation [soluble P‐selectin (sPsel), ELISA], endothelial dysfunction [von Willebrand factor (vWf), ELISA], and coagulation (fibrinogen, modified Clauss) in 16 patients (15 women, mean age 59 ± 10 years) with chronic atrial fibrillation admitted for PBMVP, and 16 healthy age‐ and gender‐matched controls. Blood samples were obtained as follows: (1) peripheral venous samples prior to PBMVP, immediately following PBMVP, and 24 h after PBMVP; and (2) arterial samples prior to and immediately following PBMVP. Results: Patients with mitral stenosis and chronic atrial fibrillation demonstrated significantly higher mean levels of vWf [148 (SD24) vs. 102 (SD 37); t‐test, p
ISSN:0160-9289
1932-8737
DOI:10.1002/clc.4960230808