Tumor lysis syndrome in pediatric acute lymphoblastic leukemia at tertiary care center

Tumor lysis syndrome (TLS) is common complication of acute lymphoblastic leukemia (ALL). It is characterized by presence of two or more of hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. TLS may cause acute kidney injury (AKI), arrhythmias and seizures. Our objective was to determin...

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Bibliographic Details
Published in:Pakistan journal of medical sciences 2019-08, Vol.35 (4), p.899-904
Main Authors: Naeem, Bilqis, Moorani, Khemchand N, Anjum, Misbah, Imam, Uzma
Format: Article
Language:English
Subjects:
Acute lymphocytic leukemia
Age
Anemia
Arrhythmia
Blood tests
Bone marrow
Cancer treatment
Cardiac arrhythmia
Chemotherapy
Dehydrogenases
Heart
Hematology
Hemoglobin
Hydration
Hyperuricemia
Hypocalcemia
Kidney failure
Kidneys
Laboratories
Leukemia
Lymphocytic leukemia
Metabolites
Morbidity
Mortality
Nervous system
Oncology
Original
Pediatrics
Phosphorus imbalance
Potassium
Rasburicase
Seizures (Medicine)
Tumors
Uric acid
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Summary:Tumor lysis syndrome (TLS) is common complication of acute lymphoblastic leukemia (ALL). It is characterized by presence of two or more of hyperkalemia, hyperuricemia, hyperphosphatemia and hypocalcemia. TLS may cause acute kidney injury (AKI), arrhythmias and seizures. Our objective was to determine the frequency of TLS and its biochemical abnormalities in children with ALL. A retrospective study on 91 children, aged 2-13 years with ALL was carried out in Nephrology and Oncology departments of National Institute of Child Health, Karachi from January 2016 to December 2017. Patients already received chemotherapy were excluded. Data including risk categories, immunophenotyping, laboratory parameters like complete blood picture, serum creatinine (SCr), potassium(K), calcium (Ca), phosphorus(P) and uric acid (UA) on day 0,3 and 7 after chemotherapy were collected. Data analyzed on SPSS using descriptive statistics. Independent t- test was applied to compare means and P- value
ISSN:1682-024X
1681-715X
DOI:10.12669/pjms.35.4.715