Mouse strain-specific acute respiratory effects of nicotine unrelated to nicotine metabolism

Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 a...

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Bibliographic Details
Published in:Toxicology mechanisms and methods 2019-09, Vol.29 (7), p.542-548
Main Author: Bloom, A. J.
Format: Article
Language:English
Subjects:
Animals
Female
Injections, Subcutaneous
Male
Mice, Inbred C3H
Mice, Inbred C57BL
mouse
nicotine
Nicotine - administration & dosage
Nicotine - blood
Nicotine - metabolism
Nicotine - toxicity
plethysmography
Plethysmography, Whole Body
Respiration
Respiration - drug effects
Species Specificity
strain
ventilation
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Summary:Plethysmograph measurement of respiratory phenotypes provides a highly sensitive means to study nicotine response in experimental model animals. We measured average respiratory frequency, tidal volume, minute volume and inspiratory time in C3H/HeJ and C57BL/6J mice subcutaneously administered 0.35 and 0.70 mg/kg nicotine. Both mouse strains showed significantly altered respiratory and locomotion phenotypes relative to saline-injected controls when administered the higher dose, but only C57BL/6J responded to the lower nicotine dose. Respiratory and locomotion phenotypes rarely differed significantly by sex. To investigate whether the strain-specific differences in nicotine sensitivity were related to differences in clearance, we followed up by measuring nicotine clearance in C3H/HeJ and C57BL/6J mice (0.35 mg/kg subcutaneous) and found sex differences in both strains, but no difference between strains.
ISSN:1537-6516
1537-6524
DOI:10.1080/15376516.2019.1628141