Effectiveness of Acupuncture in Treatment of Simple Obesity in Animal Models: A Systematic Review and Meta-Analysis

Background. Simple obesity has become a global risk to health of human beings. Acupuncture, as one of traditional Chinese medicine therapies, has been widely used in obesity treatment in recent years. However, the individual heterogeneity which makes acupuncture’s efficiency unstable leads to some c...

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Bibliographic Details
Published in:Evidence-based complementary and alternative medicine 2019, Vol.2019 (2019), p.1-36
Main Authors: Zhuang, Yi, Fu, Shu-ping, Yu, Mei-ling, Fan, Xiao-lin, Lu, Sheng-feng
Format: Article
Language:English
Subjects:
Acupuncture
Animal models
Animal research
Bias
Chinese medicine
Clinical trials
Evidence-based medicine
Health risks
Herbal medicine
Heterogeneity
Meta-analysis
Obesity
Review
Reviews
Sensitivity analysis
Systematic review
Traditional Chinese medicine
Weight reduction
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Summary:Background. Simple obesity has become a global risk to health of human beings. Acupuncture, as one of traditional Chinese medicine therapies, has been widely used in obesity treatment in recent years. However, the individual heterogeneity which makes acupuncture’s efficiency unstable leads to some controversy. So more evidence-based results are necessary to judge the effectiveness of acupuncture in treatment of simple obesity. Compared with clinical trials, animal experiments are controllable, and the underlying mechanism is more likely to be explored. Last but not the least, more and more experimental studies on acupuncture for animal obesity have been published. Therefore, we conducted the systematic review and meta-analysis to evaluate the effectiveness of acupuncture in treating simple obesity in animal experiments. Methods. Randomized Controlled Trials (RCTs) on acupuncture for simple obesity animal models were searched from six databases: PubMed, MEDLINE, CNKI, VIP, WanFang Date, and CMB from inception to February 2017 and updated on April 12, 2019. RevMan 5.3 software was used for meta-analysis. Treatment effects were summarized as relative risk (RR) and Standard mean difference (SMD) with 95% of confidence interval (CI). Results. A total of 108 trials involving 5731 rats were included. Meta-analysis showed that acupuncture had better effect on reducing weight (SMD -2.60, 95%CI: -2.93 to -2.26, p
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/5459326