Acute restraint stress reverses impaired LTP in the hippocampal CA1 region in mouse models of Alzheimer’s disease

• Published in: Scientific reports 2019-07, Vol.9 (1), p.10955-9, Article 10955
• Main Authors: Wang, Ming, Ramasamy, Vijay Sankar, Samidurai, Manikandan, Jo, Jihoon
• Format: Article
• Language: English
• Subjects: 13/1; 631/378/1689/1283; 631/378/340; 631/378/87; 64; 64/110; 64/60; 82; 82/29; 9/30; 96/95; Alzheimer Disease - metabolism; Alzheimer's disease; Animal models; Animals; CA1 Region, Hippocampal - metabolism; CA1 Region, Hippocampal - pathology; Dexamethasone; Disease Models, Animal; Glucocorticoid receptors; Hippocampal plasticity; Hippocampus; Humanities and Social Sciences; Ion channels; Long-Term Potentiation; Male; Mice; Mice, Inbred C57BL; multidisciplinary; Neuronal Plasticity; Phosphorylation; Receptors, AMPA - metabolism; Restraint, Physical - psychology; Science; Science (multidisciplinary); Stress, Psychological - metabolism; Synapses; Synaptic plasticity; Synaptic Transmission
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-019-47452-6

Acute stress facilitates long-term potentiation (LTP) in the mouse hippocampus by modulating glucocorticoid receptors and ion channels. Here, we analysed whether this occurs in mouse models of Alzheimer’s disease (AD) with impaired LTP induction. We found that a brief 30 min restraint stress protocol reversed the impaired LTP assessed with field excitatory postsynaptic potential recordings at cornu ammonis 3-1 (CA3-CA1) synapses in both Tg2576 and 5XFAD mice. This effect was accompanied by increased phosphorylation and surface expression of glutamate A1 (GluA1) -containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs). Moreover, enhanced LTP induction and GluA1 phosphorylation were sustained up to 4 h after the stress. Treatment with 200 nM dexamethasone produced similar effects in the hippocampi of these mice, which supports the glucocorticoid receptor-mediated mechanism in these models. Collectively, our results demonstrated an alleviation of impaired LTP and synaptic plasticity in the hippocampal CA1 region following acute stress in the AD mouse models.