Suppressive effect of dietary resistant maltodextrin on systemic immunity in a mouse model of food allergy

• Published in: Bioscience of Microbiota, Food and Health Food and Health, 2019, Vol.38(3), pp.89-95
• Main Authors: MIYAZATO, Shoko, TSUDA, Masato, KISHIMOTO, Yuka, HOSONO, Akira
• Format: Article
• Language: English
• Subjects: Acetic acid; Antibodies; Antigens; Biodegradation; Diet; Dietary fiber; Environmental degradation; Fatty acids; Food; Food allergies; food allergy; Goblet cells; Immune response; Immunity; Immunoglobulin A; Inflammation; Interleukin 10; Interleukin 4; Intestine; Lymph nodes; Lymphocytes T; Maltodextrin; Microbial degradation; Microorganisms; Mucosa; Propionic acid; resistant maltodextrin; Serum levels; short-chain fatty acid; Splenocytes; systemic immunity
• ISSN: 2186-3342; 2186-6953; 2186-3342
• DOI: 10.12938/bmfh.18-025

Resistant maltodextrin (RMD) is a soluble dietary fibre that exerts several physiological functions as a result of its microbial degradation and changes in the intestinal environment. It has been reported that RMD enhanced immunoglobulin A (IgA) secretion, which protects the mucosa from foreign substances. However, the effect of RMD on excessive immunity has yet to be investigated. In this study, we aimed to investigate the effect of RMD on excessive immune responses such as food allergy. OVA23-3 mice were fed an AIN-76-based diet containing 20% egg-white protein with or without RMD. While RMD was shown to contribute to an increase in goblet cells, RMD did not change the overall inflammatory status when ingested with the egg-white diet. RMD suppressed IL-4 and IL-10 production from splenocytes but not cells from mesenteric lymph nodes. RMD also downregulated the serum levels of OVA-specific Th1- and Th2-related antibodies, which were elevated in the food-allergic condition. RMD significantly increased the total amount of short-chain fatty acids, especially acetate and propionate, in the caecum of OVA23-3 mice fed the egg-white diet. Our study demonstrated that dietary RMD modulates systemic rather than intestinal antigen-specific immune responses in the food-allergic condition of OVA23-3 mice. Although the relevant mechanism has yet to be investigated, RMD shows potential for alleviating food allergy through adjustment of systemic immunity.