Parkinsonism Relating to Intoxication with Glyphosate

We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [123I]-metaiodobenzylguanidine myocardial sc...

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Bibliographic Details
Published in:Internal Medicine 2019/07/01, Vol.58(13), pp.1935-1938
Main Authors: Eriguchi, Makoto, Iida, Kotaro, Ikeda, Shuhei, Osoegawa, Manabu, Nishioka, Kenya, Hattori, Nobutaka, Nagayama, Hiroshi, Hara, Hideo
Format: Article
Language:English
Subjects:
Adult
Basal ganglia
Case Report
Central nervous system diseases
Dyskinesia
Epidemiology
Exposure
Glycine - analogs & derivatives
Glycine - toxicity
Glyphosate
Health risks
Herbicides - toxicity
Humans
Ingestion
Internal medicine
Intoxication
Levodopa
Levodopa - therapeutic use
Magnetic Resonance Imaging
Male
Movement disorders
Muscle Rigidity - chemically induced
Neurodegenerative diseases
Neuroimaging
Parkinson Disease - complications
Parkinson Disease - drug therapy
Parkinson Disease - pathology
Parkinson's disease
pesticide
Rigidity
Risk factors
Scintigraphy
Treatment Outcome
Water pollution effects
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Summary:We herein report the case of a 38-year-old man who developed parkinsonism 4 years after ingesting glyphosate. The patient presented with right-sided bradykinesia and cogwheel rigidity without autonomic symptoms. Magnetic resonance imaging of the brain and [123I]-metaiodobenzylguanidine myocardial scintigraphy were normal. A drastic response to levodopa and the presence of levodopa-induced dyskinesia without strong non-motor symptoms were seen in this patient. We considered that young-onset atypical parkinsonism was associated with a history of sublethal glyphosate ingestion. Epidemiologic investigations have shown that exposure to pesticides is a risk factor for Parkinson's disease (PD). Our findings support the notion that glyphosate exposure might be related to the onset of PD.
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2028-18