Feasibility and Value of Developing a Regional Antibiogram for Community Hospitals

OBJECTIVETo determine the feasibility and value of developing a regional antibiogram for community hospitals.DESIGNMulticenter retrospective analysis of antibiograms.SETTING AND PARTICIPANTSA total of 20 community hospitals in central and eastern North Carolina and south central Virginia participate...

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Bibliographic Details
Published in:Infection control and hospital epidemiology 2018-06, Vol.39 (6), p.718-722
Main Authors: Hostler, Christopher J, Moehring, Rebekah W, Ashley, Elizabeth S Dodds, Johnson, Melissa, Davis, Angelina, Lewis, Sarah S, Sexton, Daniel J, Anderson, Deverick J
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Antibiotics
Disease control
E coli
Escherichia coli - drug effects
Gram-Negative Bacteria - drug effects
Hospitals
Hospitals, Community
Humans
Infections
Laboratories
Microbial Sensitivity Tests
North Carolina
Nursing
Pathogens
Retrospective Studies
Virginia
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Summary:OBJECTIVETo determine the feasibility and value of developing a regional antibiogram for community hospitals.DESIGNMulticenter retrospective analysis of antibiograms.SETTING AND PARTICIPANTSA total of 20 community hospitals in central and eastern North Carolina and south central Virginia participated in this study.METHODSWe combined antibiogram data from participating hospitals for 13 clinically relevant gram-negative pathogen-antibiotic combinations. From this combined antibiogram, we developed a regional antibiogram based on the mean susceptibilities of the combined data.RESULTSWe combined a total of 69,778 bacterial isolates across 13 clinically relevant gram-negative pathogen-antibiotic combinations (median for each combination, 1100; range, 174-27,428). Across all pathogen-antibiotic combinations, 69% of local susceptibility rates fell within 1 SD of the regional mean susceptibility rate, and 97% of local susceptibilities fell within 2 SD of the regional mean susceptibility rate. No individual hospital had >1 pathogen-antibiotic combination with a local susceptibility rate >2 SD of the regional mean susceptibility rate. All hospitals' local susceptibility rates were within 2 SD of the regional mean susceptibility rate for low-prevalence pathogens (
ISSN:0899-823X
1559-6834
DOI:10.1017/ice.2018.71