When Ventricular Cerebrospinal Fluid Assessment Misleads: Basal Meningitis and the Importance of Lumbar Puncture Sampling

The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar compositio...

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Bibliographic Details
Published in:Open forum infectious diseases 2019-07, Vol.6 (7)
Main Authors: Khan, Sadid F, Macauley, Thornton, Tong, Steven Y C, Xie, Ouli, Hughes, Carly, Hall, Nicholas D P, Mahanty, Siddhartha, Jennens, Ian, Street, Alan C
Format: Article
Language:English
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Summary:The diagnosis of central nervous system (CNS) infection relies upon analysis of cerebrospinal fluid (CSF). We present 4 cases of CNS infections associated with basal meningitis and hydrocephalus with normal ventricular CSF but grossly abnormal lumbar CSF. We discuss CSF ventricular-lumbar composition gradients and putative pathophysiological mechanisms and highlight clinical clues for clinicians.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofz324