Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators

Highlights • Migraine facial allodynia was modeled in male rats by supradural “inflammatory soup” • Proinflammatory mRNAs increased in trigeminal n. caudalis as a result. • Facial allodynia was prevented by 3 chemically diverse glial modulatory drugs.

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Bibliographic Details
Published in:Brain research 2017-06, Vol.1664, p.87-94
Main Authors: Wieseler, Julie, Ellis, Amanda, McFadden, Andrew, Stone, Kendra, Brown, Kimberley, Cady, Sara, Bastos, Leandro F, Sprunger, David, Rezvani, Niloofar, Johnson, Kirk, Rice, Kenner C, Maier, Steven F, Watkins, Linda R
Format: Article
Language:English
Subjects:
Animals
Dura
Dura Mater - drug effects
Encephalitis - complications
Encephalitis - immunology
Headache
Hyperalgesia - chemically induced
Hyperalgesia - complications
Hyperalgesia - immunology
Hyperalgesia - prevention & control
Inflammation Mediators - metabolism
Interleukin-1
Macrophages - immunology
Macrophages - metabolism
Male
Microglia - immunology
Microglia - metabolism
Migraine
Migraine Disorders - complications
Minocycline - administration & dosage
Neurology
OX42
Pyridines - administration & dosage
Rats, Sprague-Dawley
Trigeminal Caudal Nucleus - drug effects
Trigeminal Caudal Nucleus - immunology
Tumor necrosis factor alpha
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Summary:Highlights • Migraine facial allodynia was modeled in male rats by supradural “inflammatory soup” • Proinflammatory mRNAs increased in trigeminal n. caudalis as a result. • Facial allodynia was prevented by 3 chemically diverse glial modulatory drugs.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2017.03.011