The Mellow Years?: Neural Basis of Improving Emotional Stability over Age

• Published in: The Journal of neuroscience 2006-06, Vol.26 (24), p.6422-6430
• Main Authors: Williams, Leanne M, Brown, Kerri J, Palmer, Donna, Liddell, Belinda J, Kemp, Andrew H, Olivieri, Gloria, Peduto, Anthony, Gordon, Evian
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Aging - physiology; Analysis of Variance; Brain - anatomy & histology; Brain - blood supply; Brain - physiology; Brain Mapping; Child; Electroencephalography - methods; Emotions - physiology; Evoked Potentials - physiology; Expressed Emotion - physiology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging - methods; Middle Aged; Oxygen - blood; Photic Stimulation - methods; Predictive Value of Tests; Regression Analysis; Self Concept
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.0022-06.2006

Contrary to the pervasive negative stereotypes of human aging, emotional functions may improve with advancing age. However, the brain mechanisms underlying changes in emotional function over age remain unknown. Here, we demonstrate that emotional stability improves linearly over seven decades (12-79 years) of the human lifespan. We used both functional magnetic resonance imaging and event-related potential recording to examine the neural basis of this improvement. With these multimodal techniques, we show that better stability is predicted by a shift toward greater medial prefrontal control over negative emotional input associated with increased activity later in the processing sequence (beyond 200 ms after stimulus) and less control over positive input, related to a decrease in early activity (within 150 ms). This shift was independent from gray matter loss, indexed by structural magnetic resonance data. We propose an integrative model in which accumulated life experience and the motivation for meaning over acquisition in older age contribute to plasticity of medial prefrontal systems, achieving a greater selective control over emotional functions.