Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin

Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of...

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Bibliographic Details
Published in:The Journal of neuroscience 2006-09, Vol.26 (38), p.9695-9702
Main Authors: Fry, Mark, Smith, Pauline M, Hoyda, Ted D, Duncan, Marnie, Ahima, Rexford S, Sharkey, Keith A, Ferguson, Alastair V
Format: Article
Language:English
Subjects:
Adipocytes - drug effects
Adipocytes - physiology
Adiponectin - administration & dosage
Adiponectin - physiology
Animals
Area Postrema - drug effects
Area Postrema - physiology
Cells, Cultured
Hormones - administration & dosage
Hormones - physiology
Male
Neurons - drug effects
Neurons - metabolism
Neurons - physiology
Rats
Rats, Sprague-Dawley
Receptors, Adiponectin
Receptors, Cell Surface - biosynthesis
RNA, Messenger - biosynthesis
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Summary:Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood-brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that approximately 60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.
ISSN:0270-6474
1529-2401
DOI:10.1523/JNEUROSCI.2014-06.2006