Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits

The present study aimed to investigate the use of computerized tomography (CT) perfusion for evaluating cerebral hemodynamics following traumatic brain injury (TBI) in rabbits. The animals were randomly assigned into four groups (n=10 animals/group): i) Control, ii) TBI, iii) TBI common decompressio...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2019-09, Vol.18 (3), p.2104-2110
Main Authors: Chen, Kefei, Dai, Feihu, Li, Guangxu, Dong, Jirong, Wang, Yuhai
Format: Article
Language:English
Subjects:
Blood
Catheters
Disability
Head injuries
Hemodynamics
Laboratory animals
Medical imaging
Medical prognosis
Rabbits
Tomography
Traumatic brain injury
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Summary:The present study aimed to investigate the use of computerized tomography (CT) perfusion for evaluating cerebral hemodynamics following traumatic brain injury (TBI) in rabbits. The animals were randomly assigned into four groups (n=10 animals/group): i) Control, ii) TBI, iii) TBI common decompression and iv) TBI controlled decompression groups. A TBI model was established in rabbits using epidural balloon inflation. In the groups receiving intervention, animals were provided common decompression or controlled decompression treatments. Conventional CT and CT perfusion scanning were performed, with cerebral hemodynamic indices, including regional cerebral blood flow (rCBF), regional cerebral blood volume (rCBV) and mean transit time (MTT) being measured. Blood-brain barrier (BBB) permeability was evaluated using Evans blue staining. Compared with those in the control group, rCBF and rCBV values of the bilateral temporal lobes and basal ganglion in the TBI, TBI + common decompression and TBI + controlled decompression groups were significantly lower, whereas the MTT values were markedly prolonged and Evans blue dye content was greatly increased (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2019.7785