Impact of Baseline ALBI Grade on the Outcomes of Hepatocellular Carcinoma Patients Treated with Lenvatinib: A Multicenter Study

This study investigated the impact of baseline liver function according to the Child-Pugh score and ALBI (albumin-bilirubin) grade on the outcomes of patients with unresectable hepatocellular carcinoma treated with lenvatinib. A total of 82 lenvatinib treated patients were included. The correlations...

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Bibliographic Details
Published in:Cancers 2019-07, Vol.11 (7), p.952
Main Authors: Ueshima, Kazuomi, Nishida, Naoshi, Hagiwara, Satoru, Aoki, Tomoko, Minami, Tomohiro, Chishina, Hirokazu, Takita, Masahiro, Minami, Yasunori, Ida, Hiroshi, Takenaka, Mamoru, Sakurai, Toshiharu, Watanabe, Tomohiro, Morita, Masahiro, Ogawa, Chikara, Hiraoka, Atsushi, Johnson, Philip, Kudo, Masatoshi
Format: Article
Language:English
Subjects:
Ascites
Bilirubin
Drug dosages
Hepatocellular carcinoma
Liver cancer
Multivariate analysis
Patients
Solid tumors
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Summary:This study investigated the impact of baseline liver function according to the Child-Pugh score and ALBI (albumin-bilirubin) grade on the outcomes of patients with unresectable hepatocellular carcinoma treated with lenvatinib. A total of 82 lenvatinib treated patients were included. The correlations of baseline liver function according to the Child-Pugh score and ALBI grade with treatment outcomes, including objective response rate per mRECIST (modified Response Evaluation Criteria in the Solid Tumor), time to treatment failure, treatment duration, and likelihood of treatment discontinuation due to adverse events, were assessed in patients with hepatocellular carcinoma treated with lenvatinib. Patients were divided into four groups: (1) Child-Pugh score 5 and ALBI grade 1 (group 1), (2) Child-Pugh score 5 and ALBI grade 2 (group 2), (3) Child-Pugh score 6 (group 3), and (4) Child-Pugh score ≥7 (group 4). Univariate and multivariate analyses were performed to identify the factors contributing to the objective response rate and likelihood of discontinuation due to adverse events. Among the 82 patients analyzed, group 1 had the highest objective response rate (57.1%) and the lowest likelihood of treatment discontinuation because of adverse events (11.1%) among the four groups ( < 0.05 and < 0.05). Multivariate analysis identified ALBI grade 1 and baseline AFP level
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers11070952