Platelets Are Critical Key Players in Sepsis

Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of ma...

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Bibliographic Details
Published in:International journal of molecular sciences 2019-07, Vol.20 (14), p.3494
Main Authors: Vardon-Bounes, Fanny, Ruiz, Stéphanie, Gratacap, Marie-Pierre, Garcia, Cédric, Payrastre, Bernard, Minville, Vincent
Format: Article
Language:English
Subjects:
Animals
Bacterial Toxins - toxicity
Blood platelets
Blood Platelets - immunology
Blood Platelets - pathology
Cardiology and cardiovascular system
Collagen
Endothelium, Vascular - immunology
Endothelium, Vascular - pathology
Fibrinogen
Fibronectin
Glycoproteins
Human health and pathology
Humans
Intensive care
Laboratories
Laminin
Life Sciences
Mortality
Neutrophils
Pathogens
Review
Sepsis
Sepsis - blood
Sepsis - complications
Septic shock
Thrombocytopenia
Thrombocytopenia - blood
Thrombocytopenia - etiology
Thrombosis
Thrombospondin
Von Willebrand factor
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Summary:Host defense against infection is based on two crucial mechanisms: the inflammatory response and the activation of coagulation. Platelets are involved in both hemostasis and immune response. These mechanisms work together in a complex and synchronous manner making the contribution of platelets of major importance in sepsis. This is a summary of the pathophysiology of sepsis-induced thrombocytopenia, microvascular consequences, platelet-endothelial cells and platelet-pathogens interactions. The critical role of platelets during sepsis and the therapeutic implications are also reviewed.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20143494