Redox Control of Vascular Biology

VEGF could enhance the migration of leukocytes into psoriatic skin and increase oxygen consumption, further activating HIF-1α and perpetuating the angiogenic/inflammatory cycle of psoriasis. [...]ROS-VEGF signaling may be a potential target for the treatment of psoriasis. In the review by N. Mahajan...

Full description

Saved in:
Bibliographic Details
Published in:Oxidative medicine and cellular longevity 2019, Vol.2019, p.3764252-2
Main Authors: Banerjee, J., Ghose, J., Sinha, M., Sen, S.
Format: Article
Language:English
Subjects:
Angiogenesis
Antioxidants
Biology
Biology - methods
Conflicts of interest
Diabetes
Diabetic retinopathy
Disease
DNA methylation
Enzymes
Humans
Hypertension
Inflammation
Insulin resistance
Ischemia
Kinases
Metabolism
MicroRNAs
Mitochondrial DNA
Nitric oxide
Oxidation-Reduction
Oxidative stress
Physiological aspects
Psoriasis
Skin
Skin diseases
Superoxide
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:VEGF could enhance the migration of leukocytes into psoriatic skin and increase oxygen consumption, further activating HIF-1α and perpetuating the angiogenic/inflammatory cycle of psoriasis. [...]ROS-VEGF signaling may be a potential target for the treatment of psoriasis. In the review by N. Mahajan et al., the authors discuss how impaired biochemical redox pathways contribute to diabetic retinopathy highlighting the role of increased influx in polyol, accumulation of advanced end glycation products (AGE), enhanced activation of hexosamine, protein kinase C (PKC), and tissue renin-angiotensin system (RAS). The authors summarize that the overall effects of the metabolic abnormalities result in augmentation of ROS (reactive oxygen species) and RNS (reactive nitrogen species) production and associated oxidative and nitrosative damage, thereby leading to retinal vascular dysfunctions in DR. They also discuss the importance of metabolic memory caused by epigenetic changes such as a modified DNA methylation pattern, altered histone modifications of key regulatory proteins and altered microRNA (miRNA) expression leading to altered mitochondrial enzymes, damage to mitochondrial DNA, and altered mitochondrial ETC complexes.
ISSN:1942-0900
1942-0994
DOI:10.1155/2019/3764252