CK‐2127107 amplifies skeletal muscle response to nerve activation in humans

• Published in: Muscle & nerve 2018-05, Vol.57 (5), p.729-734
• Main Authors: Andrews, Jinsy A., Miller, Timothy M., Vijayakumar, Vipin, Stoltz, Randall, James, Joyce K., Meng, Lisa, Wolff, Andrew A., Malik, Fady I.
• Format: Article
• Language: English
• Subjects: Calcium-binding protein; CK‐2127107; Clinical Research; fast skeletal muscle troponin activator; force‐frequency relationship; Frequency dependence; Frequency response; Muscles; Musculoskeletal system; Pharmacodynamics; Pharmacokinetics; Pharmacology; phase 1; Skeletal muscle; Tibialis anterior muscle; Troponin
• ISSN: 0148-639X; 1097-4598
• DOI: 10.1002/mus.26017

ABSTRACT Introduction Three studies evaluated safety, tolerability, pharmacokinetics, and pharmacodynamics of CK‐2127107 (CK‐107), a next‐generation fast skeletal muscle troponin activator (FSTA), in healthy participants. We tested the hypothesis that CK‐107 would amplify the force‐frequency response of muscle in humans. Methods: To assess the force‐frequency response, participants received single doses of CK‐107 and placebo in a randomized, double‐blind, 4‐period, crossover study. The force‐frequency response of foot dorsiflexion following stimulation of the deep fibular nerve to activate the tibialis anterior muscle was assessed. Results: CK‐107 significantly increased tibialis anterior muscle response with increasing dose and plasma concentration in a frequency‐dependent manner; the largest increase in peak force was ∼60% at 10 Hz. Discussion: CK‐107 appears more potent and produced larger increases in force than tirasemtiv—a first‐generation FSTA—in a similar pharmacodynamic study, thereby supporting its development for improvement of muscle function of patients. Muscle Nerve 57: 729–734, 2018