The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous pa...

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Bibliographic Details
Published in:Scientific reports 2019-08, Vol.9 (1), p.11299-8, Article 11299
Main Authors: Agnifili, Luca, Brescia, Lorenza, Oddone, Francesco, Sacchi, Matteo, D’Ugo, Erminia, Di Marzio, Guido, Perna, Fabiana, Costagliola, Ciro, Mastropasqua, Rodolfo
Format: Article
Language:English
Subjects:
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Aged
Cell Count
Cell density
Cellular biology
Confocal microscopy
Cornea
Cytology
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - pathology
Eye surgery
Female
Filtering Surgery
Filtration
Glaucoma
Glaucoma - diagnostic imaging
Glaucoma - pathology
Glaucoma - surgery
Goblet Cells - cytology
Goblet Cells - pathology
Histocompatibility antigen HLA
Humanities and Social Sciences
Humans
Male
Meibomian Glands - diagnostic imaging
Meibomian Glands - pathology
Microscopy
Microscopy, Confocal
Middle Aged
multidisciplinary
Patients
Science
Science (multidisciplinary)
Surgery
Visual perception
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Summary:We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-47823-z