The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study

We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous pa...

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Published in:Scientific reports 2019-08, Vol.9 (1), p.11299-8, Article 11299
Main Authors: Agnifili, Luca, Brescia, Lorenza, Oddone, Francesco, Sacchi, Matteo, D’Ugo, Erminia, Di Marzio, Guido, Perna, Fabiana, Costagliola, Ciro, Mastropasqua, Rodolfo
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Language:English
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13/1
13/51
14
14/19
692/699
692/699/3161/3162
692/699/3161/3163
692/699/3161/3169/3170
692/699/3161/3172
Aged
Cell Count
Cell density
Cellular biology
Confocal microscopy
Cornea
Cytology
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - pathology
Eye surgery
Female
Filtering Surgery
Filtration
Glaucoma
Glaucoma - diagnostic imaging
Glaucoma - pathology
Glaucoma - surgery
Goblet Cells - cytology
Goblet Cells - pathology
Histocompatibility antigen HLA
Humanities and Social Sciences
Humans
Male
Meibomian Glands - diagnostic imaging
Meibomian Glands - pathology
Microscopy
Microscopy, Confocal
Middle Aged
multidisciplinary
Patients
Science
Science (multidisciplinary)
Surgery
Visual perception
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creator Agnifili, Luca
Brescia, Lorenza
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Perna, Fabiana
Costagliola, Ciro
Mastropasqua, Rodolfo
description We investigated the ocular surface (OS) system modifications after completely successful glaucoma surgery in thirty-eight patients undergoing trabeculectomy (surgical group), using laser scanning confocal microscopy (LSCM) and impression cytology (IC). Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p 
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Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p < 0.001), and a LDCD, SCNI, MGI, HLA-DR (p < 0.001), OSDI and NEI VFQ-25 scores decrease (p < 0.05). The medical group did not show significant OS modifications, showing LSCM and IC parameters significantly worse compared to the surgical group (p < 0.001). The OSDI score correlated with GCD, MGI, SCNI, LDCD, and HLA-DR (p < 0.001; p < 0.05; p < 0.01). The present study found that the whole OS system objectively improved after completely successful glaucoma filtration surgery. These changes positively affected the OSDI score, but not the NEI VFQ-25 score.]]></description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-019-47823-z</identifier><identifier>PMID: 31383900</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/1 ; 13/51 ; 14 ; 14/19 ; 692/699 ; 692/699/3161/3162 ; 692/699/3161/3163 ; 692/699/3161/3169/3170 ; 692/699/3161/3172 ; Aged ; Cell Count ; Cell density ; Cellular biology ; Confocal microscopy ; Cornea ; Cytology ; Dendritic cells ; Dendritic Cells - cytology ; Dendritic Cells - pathology ; Eye surgery ; Female ; Filtering Surgery ; Filtration ; Glaucoma ; Glaucoma - diagnostic imaging ; Glaucoma - pathology ; Glaucoma - surgery ; Goblet Cells - cytology ; Goblet Cells - pathology ; Histocompatibility antigen HLA ; Humanities and Social Sciences ; Humans ; Male ; Meibomian Glands - diagnostic imaging ; Meibomian Glands - pathology ; Microscopy ; Microscopy, Confocal ; Middle Aged ; multidisciplinary ; Patients ; Science ; Science (multidisciplinary) ; Surgery ; Visual perception</subject><ispartof>Scientific reports, 2019-08, Vol.9 (1), p.11299-8, Article 11299</ispartof><rights>The Author(s) 2019</rights><rights>2019. 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Twenty-six medically controlled glaucomatous patients served as controls (medical group). LSCM, IC, and the ocular surface disease index (OSDI) and National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) questionnaires, were performed at baseline and after six months. The main outcomes were: goblet cell density (GCD), limbal dendritic cell density (LDCD), subbasal corneal nerve inhomogeneity (SCNI), Meibomian gland density and inhomogeneity (MGD, MGI), and HLA-DR positivity. There were no significant baseline differences between groups. At the sixth month, the surgical group showed a GCD increase (p < 0.001), and a LDCD, SCNI, MGI, HLA-DR (p < 0.001), OSDI and NEI VFQ-25 scores decrease (p < 0.05). The medical group did not show significant OS modifications, showing LSCM and IC parameters significantly worse compared to the surgical group (p < 0.001). The OSDI score correlated with GCD, MGI, SCNI, LDCD, and HLA-DR (p < 0.001; p < 0.05; p < 0.01). The present study found that the whole OS system objectively improved after completely successful glaucoma filtration surgery. These changes positively affected the OSDI score, but not the NEI VFQ-25 score.]]></abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31383900</pmid><doi>10.1038/s41598-019-47823-z</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-1625-6305</orcidid><oa>free_for_read</oa></addata></record>
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subjects 13/1
13/51
14
14/19
692/699
692/699/3161/3162
692/699/3161/3163
692/699/3161/3169/3170
692/699/3161/3172
Aged
Cell Count
Cell density
Cellular biology
Confocal microscopy
Cornea
Cytology
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - pathology
Eye surgery
Female
Filtering Surgery
Filtration
Glaucoma
Glaucoma - diagnostic imaging
Glaucoma - pathology
Glaucoma - surgery
Goblet Cells - cytology
Goblet Cells - pathology
Histocompatibility antigen HLA
Humanities and Social Sciences
Humans
Male
Meibomian Glands - diagnostic imaging
Meibomian Glands - pathology
Microscopy
Microscopy, Confocal
Middle Aged
multidisciplinary
Patients
Science
Science (multidisciplinary)
Surgery
Visual perception
title The ocular surface after successful glaucoma filtration surgery: a clinical, in vivo confocal microscopy, and immune-cytology study
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