A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients

A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM li...

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Bibliographic Details
Published in:Scientific reports 2019-08, Vol.9 (1), p.11308-8, Article 11308
Main Authors: Zhou, Neng, Zou, Caiyuan, Qin, Menglin, Li, Yi, Huang, Jiayi
Format: Article
Language:English
Subjects:
631/92
692/4017
Animals
Anti-Inflammatory Agents - pharmacokinetics
Anti-Inflammatory Agents - pharmacology
Chinese medicine
Drug interaction
Drug interactions
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - pharmacology
Female
Glycyrrhetinic Acid - pharmacokinetics
Glycyrrhetinic Acid - pharmacology
Glycyrrhiza - chemistry
Herb-Drug Interactions
Herbal medicine
High-performance liquid chromatography
Humanities and Social Sciences
Liquid chromatography
Male
multidisciplinary
Pharmacokinetics
Rats, Sprague-Dawley
Science
Science (multidisciplinary)
Traditional Chinese medicine
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Summary:A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t 1/2 ), time to peak concentration(T max ) and peak concentration C max were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-47880-4