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A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients
A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM li...
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| Published in: | Scientific reports 2019-08, Vol.9 (1), p.11308-8, Article 11308 |
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| creator | Zhou, Neng Zou, Caiyuan Qin, Menglin Li, Yi Huang, Jiayi |
| description | A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t
1/2
), time to peak concentration(T
max
) and peak concentration C
max
were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM. |
| doi_str_mv | 10.1038/s41598-019-47880-4 |
| format | article |
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1/2
), time to peak concentration(T
max
) and peak concentration C
max
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1/2
), time to peak concentration(T
max
) and peak concentration C
max
were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM.</description><subject>631/92</subject><subject>692/4017</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents - pharmacokinetics</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Chinese medicine</subject><subject>Drug interaction</subject><subject>Drug interactions</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Female</subject><subject>Glycyrrhetinic Acid - pharmacokinetics</subject><subject>Glycyrrhetinic Acid - pharmacology</subject><subject>Glycyrrhiza - chemistry</subject><subject>Herb-Drug Interactions</subject><subject>Herbal medicine</subject><subject>High-performance liquid chromatography</subject><subject>Humanities and Social Sciences</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>multidisciplinary</subject><subject>Pharmacokinetics</subject><subject>Rats, Sprague-Dawley</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Traditional Chinese medicine</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNp9UctqFjEUDqLYUvsCLiTgejTXSbIRSvEGBTe6DrnNTOpMMiYzlf8BfG_T_rXWjWeRc8j5Lgc-AF5i9AYjKt9WhrmSHcKqY0JK1LEn4JQgxjtCCXn6aD4B57Veo1acKIbVc3BCMZVUEXEKfl3AGpd1DnAJ25Q9HHKB4cbMu9liTnCdTFmMy99jClt0FeYBjvPBHUqZ2keKDhoXPTTJwzVvIW3RzNCXfexuHxjTFopxd1o2bD9DSHAKxTZQTGMJPjZKfQGeDWau4fy-n4FvH95_vfzUXX35-Pny4qpzHOOtE9YirgwVJgQsnTLGWOmQZERJ7hUTTqHekkFYwyjlcuBKMYmF6P3ArXf0DLw76q67XYJ3zbuYWa8lLqYcdDZR_7tJcdJjvtF9LylFuAm8vhco-cce6qav815Su1kT0kuhEGWkocgR5UqutYThwQEjfZuePqanW3r6Lj3NGunV49seKH-yagB6BNS2SmMof73_I_sbIRqpuA</recordid><startdate>20190805</startdate><enddate>20190805</enddate><creator>Zhou, Neng</creator><creator>Zou, Caiyuan</creator><creator>Qin, Menglin</creator><creator>Li, Yi</creator><creator>Huang, Jiayi</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope></search><sort><creationdate>20190805</creationdate><title>A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients</title><author>Zhou, Neng ; Zou, Caiyuan ; Qin, Menglin ; Li, Yi ; Huang, Jiayi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-7bb059a37aee18c9aaab8c0842985d947c906b2f7ba43358f599481776df5bdc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>631/92</topic><topic>692/4017</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents - pharmacokinetics</topic><topic>Anti-Inflammatory Agents - pharmacology</topic><topic>Chinese medicine</topic><topic>Drug interaction</topic><topic>Drug interactions</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Female</topic><topic>Glycyrrhetinic Acid - pharmacokinetics</topic><topic>Glycyrrhetinic Acid - pharmacology</topic><topic>Glycyrrhiza - chemistry</topic><topic>Herb-Drug Interactions</topic><topic>Herbal medicine</topic><topic>High-performance liquid chromatography</topic><topic>Humanities and Social Sciences</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>multidisciplinary</topic><topic>Pharmacokinetics</topic><topic>Rats, Sprague-Dawley</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhou, Neng</creatorcontrib><creatorcontrib>Zou, Caiyuan</creatorcontrib><creatorcontrib>Qin, Menglin</creatorcontrib><creatorcontrib>Li, Yi</creatorcontrib><creatorcontrib>Huang, Jiayi</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Science Journals</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Neng</au><au>Zou, Caiyuan</au><au>Qin, Menglin</au><au>Li, Yi</au><au>Huang, Jiayi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2019-08-05</date><risdate>2019</risdate><volume>9</volume><issue>1</issue><spage>11308</spage><epage>8</epage><pages>11308-8</pages><artnum>11308</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>A simple validated high performance liquid chromatography method was developed for the evaluation of the effect of three kinds of active ingredients in traditional Chinese medicine (TCM) on the pharmacokinetics of glycyrrhetinic acid (GA),a kind of active component from the most commonly used TCM licorice. Our results revealed that all of the calibration curves displayed good linearity. Intra- and inter-day precision for GA ranged from 2.54 to 3.98% and from 4.95 to 7.08%, respectively. The recovery rates for GA were determined to be 96.3–106.4%. All the samples showed satisfactory precision and accuracy in various stability tests. Plasma pharmacokinetic parameters including area under the concentration-time curve (AUC), elimination half-life (t
1/2
), time to peak concentration(T
max
) and peak concentration C
max
were calculated. No significant difference was found as compared the groups administrating GA with and without other ingredients from TCM.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>31383927</pmid><doi>10.1038/s41598-019-47880-4</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| source | Open Access: PubMed Central; Publicly Available Content Database; Free Full-Text Journals in Chemistry; Springer Nature - nature.com Journals - Fully Open Access |
| subjects | 631/92 692/4017 Animals Anti-Inflammatory Agents - pharmacokinetics Anti-Inflammatory Agents - pharmacology Chinese medicine Drug interaction Drug interactions Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Female Glycyrrhetinic Acid - pharmacokinetics Glycyrrhetinic Acid - pharmacology Glycyrrhiza - chemistry Herb-Drug Interactions Herbal medicine High-performance liquid chromatography Humanities and Social Sciences Liquid chromatography Male multidisciplinary Pharmacokinetics Rats, Sprague-Dawley Science Science (multidisciplinary) Traditional Chinese medicine |
| title | A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients |
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