Oral Mycosis Fungoides: A Report of Three Cases and Review of the Literature

Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very...

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Bibliographic Details
Published in:Head & neck pathology (Totowa, N.J.) N.J.), 2019-09, Vol.13 (3), p.492-499
Main Authors: Rosebush, Molly S., Allen, Carl M., Accurso, Brent T., Baiocchi, Robert A., Cordell, Kitrina G.
Format: Article
Language:English
Subjects:
Aged
Case Report
Dentistry
Female
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Mouth Neoplasms - pathology
Mycosis Fungoides - pathology
Oral and Maxillofacial Surgery
Otorhinolaryngology
Pathology
Skin Neoplasms - pathology
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Summary:Mycosis fungoides (MF) and Sézary syndrome are clonal T-cell proliferations that exhibit skin homing and represent the majority of cutaneous T-cell lymphomas. Early MF is a diagnostic challenge as both the clinical and microscopic features often mimic benign inflammatory conditions. Oral MF is very rare and has been associated in the past with advanced disease and a poor prognosis. Skin lesions are present for an average of > 6 years before oral involvement occurs. The clinical appearance is highly variable with tongue, palate and gingiva most often affected. We report 3 additional cases of oral MF, including one in which oral lesions are the initial disease presentation. Survival in patients presenting with oral MF is improving and can be attributed to advances in therapy.
ISSN:1936-0568
1936-055X
1936-0568
DOI:10.1007/s12105-018-0923-5