A novel inducible acute hyperglycemia mouse model for assessing 6-KTP

The aim of the present study was to establish a mouse model of acute hyperglycemia, which may be utilized to detect the glucose concentration-dependent hypoglycemic activity of the glucagon-like peptide-1 derivative, 6-KTP. The results demonstrated that the first 30 min following the intraperitoneal...

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Bibliographic Details
Published in:Biomedical reports 2019-09, Vol.11 (3), p.110-114
Main Authors: Hu, Jinrui, Zhong, Xia, Yang, Xiaoping, Li, Hongjian, Ran, Yanhong
Format: Article
Language:English
Subjects:
Analysis
Animal models
Biological activity
Blood glucose
Diabetes
Diabetes mellitus
Drug dosages
Glucagon
Glucagon-like peptide 1
Glucose
Health aspects
House mouse
Hyperglycemia
In vivo methods and tests
Insulin
Laboratory animals
Liraglutide
Methods
Peptides
Software industry
Studies
Therapeutics
Toxicology
Type 2 diabetes
Veins & arteries
Citations: Items that this one cites
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Description
Summary:The aim of the present study was to establish a mouse model of acute hyperglycemia, which may be utilized to detect the glucose concentration-dependent hypoglycemic activity of the glucagon-like peptide-1 derivative, 6-KTP. The results demonstrated that the first 30 min following the intraperitoneal injection of 2 g/kg glucose into C57BL/6J mice was the optimum time for assessing the hypoglycemic activity of potential therapeutic methods for diabetes. There was a linear association between the dose of 6-KTP and hypoglycemic activity between 0.2 and 1.2 mg/kg. The resulting model may serve as template for developing cost-effective in vivo models to test similar therapeutics.
ISSN:2049-9434
2049-9442
DOI:10.3892/br.2019.1228