Thymoma-associated multiorgan autoimmunity

Thymoma-associated multiorgan autoimmunity is a relatively new term to describe the rare paraneoplastic syndrome that complicates thymoma, which can involve the thyroid, liver and intestine in addition to the skin. The pathology often indicates a graft-versus-host-like pattern commonly observed in r...

Full description

Saved in:
Bibliographic Details
Published in:BMJ case reports 2019-08, Vol.12 (8), p.e229163
Main Authors: Hung, Chien-Tzu, Tsai, Tsen-Fang, Chen, Jin-Shing, Hsieh, Min-Shu
Format: Article
Language:English
Subjects:
Autoimmune Diseases - drug therapy
Autoimmune Diseases - etiology
Blood
Case reports
Combined Modality Therapy
Cytomegalovirus
Dermatitis
Disease
Drug dosages
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Image-Guided Biopsy
Immunoglobulins
Inflammation
Lichen Planus, Oral - etiology
Lung - diagnostic imaging
Lung - pathology
Lupus
Male
Middle Aged
Neoplasm Invasiveness
Ostomy
Pleura - pathology
Rare Disease
Respiration
Skin
Skin diseases
Thymoma - complications
Thymoma - pathology
Thymoma - surgery
Thymus Neoplasms - complications
Thymus Neoplasms - pathology
Thymus Neoplasms - surgery
Thyroid gland
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thymoma-associated multiorgan autoimmunity is a relatively new term to describe the rare paraneoplastic syndrome that complicates thymoma, which can involve the thyroid, liver and intestine in addition to the skin. The pathology often indicates a graft-versus-host-like pattern commonly observed in recipients of an allogeneic haematopoietic cell transplant. We report a case of type B2 and B3 thymoma with invasion to the lung and pleura in a patient who presented with oral lichen planus and graft-versus-host-like erythroderma. The cutaneous lesions improved after complete resection of the thymoma in combination with systemic glucocorticoids, which was subsequently complicated by cytomegalovirus pneumonitis.
ISSN:1757-790X
1757-790X
DOI:10.1136/bcr-2018-229163