Dynamic Causal Modelling of Active Vision

• Published in: The Journal of neuroscience 2019-08, Vol.39 (32), p.6265-6275
• Main Authors: Parr, Thomas, Mirza, M Berk, Cagnan, Hayriye, Friston, Karl J
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Attention - physiology; Brain; Causality; Connectome; Cortex (frontal); Culture; Dominance, Cerebral; Eye; Eye movements; Female; Fixation, Ocular - physiology; Frontal Lobe - physiology; Humans; Interrogation; Magnetoencephalography; Male; Mapping; Models, Neurological; Modulation; Nerve Net - physiology; Neural networks; Parietal Lobe - physiology; Perceptual Disorders - physiopathology; Photic Stimulation; Saccades - physiology; Saccadic eye movements; Synapses; Temporal Lobe - physiology; Visual cortex; Visual Pathways - physiology; Visual Perception - physiology; Young Adult
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/JNEUROSCI.2459-18.2019

In this paper, we draw from recent theoretical work on active perception, which suggests that the brain makes use of an internal (i.e., generative) model to make inferences about the causes of sensations. This view treats visual sensations as consequent on action (i.e., saccades) and implies that visual percepts must be actively constructed via a sequence of eye movements. Oculomotor control calls on a distributed set of brain sources that includes the dorsal and ventral frontoparietal (attention) networks. We argue that connections from the frontal eye fields to ventral parietal sources represent the mapping from "where", fixation location to information derived from "what" representations in the ventral visual stream. During scene construction, this mapping must be learned, putatively through changes in the effective connectivity of these synapses. Here, we test the hypothesis that the coupling between the dorsal frontal cortex and the right temporoparietal cortex is modulated during saccadic interrogation of a simple visual scene. Using dynamic causal modeling for magnetoencephalography with (male and female) human participants, we assess the evidence for changes in effective connectivity by comparing models that allow for this modulation with models that do not. We find strong evidence for modulation of connections between the two attention networks; namely, a disinhibition of the ventral network by its dorsal counterpart. This work draws from recent theoretical accounts of active vision and provides empirical evidence for changes in synaptic efficacy consistent with these computational models. In brief, we used magnetoencephalography in combination with eye-tracking to assess the neural correlates of a form of short-term memory during a dot cancellation task. Using dynamic causal modeling to quantify changes in effective connectivity, we found evidence that the coupling between the dorsal and ventral attention networks changed during the saccadic interrogation of a simple visual scene. Intuitively, this is consistent with the idea that these neuronal connections may encode beliefs about "what I would see if I looked there", and that this mapping is optimized as new data are obtained with each fixation.