Immunodeficiency and Epstein Barr virus induced lymphoproliferation caused by 4-1BB deficiency

We have identified a novel immunodeficiency associated with EBV induced lymphoproliferation due to a homozygous missense mutation in 4-1BB, demonstrating a critical role for 4-1BB in the human immune response against EBV-driven B cell lymphoproliferation.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2019-03, Vol.144 (2), p.574-583.e5
Main Authors: Alosaimi, Mohammed, Hoenig, Manfred, Jaber, Faris, Platt, Craig D., Jones, Jennifer, Wallace, Jacqueline, Debatin, Klaus-Michael, Schulz, Ansgar, Jacobsen, Eva, Möller, Peter, Shamseldin, Hanan E., Abdulwahab, Ferdous, Ibrahim, Niema, Alardati, Hosam, Almuhizi, Faisal, Abosoudah, Ibraheem F., Basha, Talal A., Chou, Janet, Alkuraya, Fowzan S., Geha, Raif S.
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:We have identified a novel immunodeficiency associated with EBV induced lymphoproliferation due to a homozygous missense mutation in 4-1BB, demonstrating a critical role for 4-1BB in the human immune response against EBV-driven B cell lymphoproliferation.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2019.03.002