Color and orientation are jointly coded and spatially organized in primate primary visual cortex

Previous studies support the textbook model that shape and color are extracted by distinct neurons in primate primary visual cortex (V1). However, rigorous testing of this model requires sampling a larger stimulus space than previously possible. We used stable GCaMP6f expression and two-photon calci...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2019-06, Vol.364 (6447), p.1275-1279
Main Authors: Garg, Anupam K, Li, Peichao, Rashid, Mohammad S, Callaway, Edward M
Format: Article
Language:English
Subjects:
Animals
Brain
Calcium
Calcium imaging
Color
Color Perception - physiology
Columns (structural)
Computer architecture
Cytochromes
Electron Transport Complex IV - metabolism
Female
Histology
Information processing
Macaca fascicularis
Neuroimaging
Neurons
Orientation
Orientation - physiology
Orientation behavior
Selectivity
Spatial analysis
Spatial Behavior - physiology
Stimuli
Visual cortex
Visual Cortex - physiology
Visual Cortex - ultrastructure
Visual pathways
Visual perception
Visual stimuli
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Summary:Previous studies support the textbook model that shape and color are extracted by distinct neurons in primate primary visual cortex (V1). However, rigorous testing of this model requires sampling a larger stimulus space than previously possible. We used stable GCaMP6f expression and two-photon calcium imaging to probe a very large spatial and chromatic visual stimulus space and map functional microarchitecture of thousands of neurons with single-cell resolution. Notable proportions of V1 neurons strongly preferred equiluminant color over achromatic stimuli and were also orientation selective, indicating that orientation and color in V1 are mutually processed by overlapping circuits. Single neurons could precisely and unambiguously code for both color and orientation. Further analyses revealed systematic spatial relationships between color tuning, orientation selectivity, and cytochrome oxidase histology.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.aaw5868