Talking Genes in Breast and Pancreatic Malignancies

Both breast and pancreatic cancers have high mortality rates. Breast cancer is while pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death. Almost 4-16 % of individuals with pancreatic cancer have a family history of the disease. Intra-ductal papillary mucinous neop...

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Bibliographic Details
Published in:Materia socio-medica 2019-06, Vol.31 (2), p.146-149
Main Authors: Barbara, Mary, Tsen, Adrianne, Tenner, Laura, Rosenkranz, Laura
Format: Article
Language:English
Subjects:
Breast cancer
Mutation
Pancreatic cancer
Review
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Summary:Both breast and pancreatic cancers have high mortality rates. Breast cancer is while pancreatic ductal adenocarcinoma (PDAC) is the fourth most common cause of cancer death. Almost 4-16 % of individuals with pancreatic cancer have a family history of the disease. Intra-ductal papillary mucinous neoplasms (IPMNs) are cystic lesions that received more attention lately due to their associations with PDAC and other solid organ tumors, such as breast cancer. The purpose of this article is to discuss the association of the familiar pancreatic cancer (FPC), sporadic pancreatic cancer, and IPMNs with the breast cancer. Data is insufficient to prove an association between IPMNs and breast cancer. The familial clustering of PDAC is not well understood. Further studies are required for greater comprehension of the genetic basis of PDAC and the association between IPMNs and breast cancer.
ISSN:1512-7680
1986-597X
DOI:10.5455/msm.2019.31.146-149