Sex differences in fear extinction

Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreove...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience and biobehavioral reviews 2019-08, Vol.103, p.81-108
Main Authors: Velasco, E.R., Florido, A., Milad, M.R., Andero, R.
Format: Article
Language:English
Subjects:
Animals
Brain - physiology
Extinction
Extinction, Psychological - physiology
Fear
Fear - physiology
Female
Human
Humans
Male
Rodent
Sex
Sex Characteristics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3
cites cdi_FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3
container_end_page 108
container_issue
container_start_page 81
container_title Neuroscience and biobehavioral reviews
container_volume 103
creator Velasco, E.R.
Florido, A.
Milad, M.R.
Andero, R.
description Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreover, the exact contribution of sex and hormones in relation to learning and behavior is still largely unknown. Insights from this field could be beneficial as fear-related disorders are twice as prevalent in women compared to men. Here, we review an up-to-date summary of animal and human studies in adulthood that report sex differences in fear extinction from a structural and functional approach. Furthermore, we describe how these factors could contribute to the observed sex differences in fear extinction during normal and pathological conditions.
doi_str_mv 10.1016/j.neubiorev.2019.05.020
format article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6692252</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149763418308820</els_id><sourcerecordid>2232115756</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3</originalsourceid><addsrcrecordid>eNqFkMtOwzAQRS0EoqXwCxCxYpPgZ5xskFDFS6rEAlhbjjMGV2lc7LQqf0-ilgpWrGYxZ-4dHYQuCM4IJvn1PGthVTkfYJ1RTMoMiwxTfIDGpJAslYIWh2iMCS9TmTM-QicxzjHuESaO0YgRQkvKxBhdvsAmqZ21EKA1EBPXJhZ0SGDTudZ0zren6MjqJsLZbk7Q2_3d6_QxnT0_PE1vZ6nhUnQpcIs1riooNSdcC8m11LUBS0CCLipd4QIYF5bkZSVyAtgUBS50XUqRc2rYBN1sc5eragH9ZdsF3ahlcAsdvpTXTv3dtO5Dvfu1yvOSUkH7gKtdQPCfK4idWrhooGl0C34VFaWMEiL6uh6VW9QEH2MAu68hWA2G1VztDavBsMJCDfom6Pz3l_u7H6U9cLsFoHe1dhBUNG5wW7sAplO1d_-WfANQPpHj</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232115756</pqid></control><display><type>article</type><title>Sex differences in fear extinction</title><source>ScienceDirect Journals</source><creator>Velasco, E.R. ; Florido, A. ; Milad, M.R. ; Andero, R.</creator><creatorcontrib>Velasco, E.R. ; Florido, A. ; Milad, M.R. ; Andero, R.</creatorcontrib><description>Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreover, the exact contribution of sex and hormones in relation to learning and behavior is still largely unknown. Insights from this field could be beneficial as fear-related disorders are twice as prevalent in women compared to men. Here, we review an up-to-date summary of animal and human studies in adulthood that report sex differences in fear extinction from a structural and functional approach. Furthermore, we describe how these factors could contribute to the observed sex differences in fear extinction during normal and pathological conditions.</description><identifier>ISSN: 0149-7634</identifier><identifier>ISSN: 1873-7528</identifier><identifier>EISSN: 1873-7528</identifier><identifier>DOI: 10.1016/j.neubiorev.2019.05.020</identifier><identifier>PMID: 31129235</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Brain - physiology ; Extinction ; Extinction, Psychological - physiology ; Fear ; Fear - physiology ; Female ; Human ; Humans ; Male ; Rodent ; Sex ; Sex Characteristics</subject><ispartof>Neuroscience and biobehavioral reviews, 2019-08, Vol.103, p.81-108</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3</citedby><cites>FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3</cites><orcidid>0000-0002-8778-5618</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31129235$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Velasco, E.R.</creatorcontrib><creatorcontrib>Florido, A.</creatorcontrib><creatorcontrib>Milad, M.R.</creatorcontrib><creatorcontrib>Andero, R.</creatorcontrib><title>Sex differences in fear extinction</title><title>Neuroscience and biobehavioral reviews</title><addtitle>Neurosci Biobehav Rev</addtitle><description>Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreover, the exact contribution of sex and hormones in relation to learning and behavior is still largely unknown. Insights from this field could be beneficial as fear-related disorders are twice as prevalent in women compared to men. Here, we review an up-to-date summary of animal and human studies in adulthood that report sex differences in fear extinction from a structural and functional approach. Furthermore, we describe how these factors could contribute to the observed sex differences in fear extinction during normal and pathological conditions.</description><subject>Animals</subject><subject>Brain - physiology</subject><subject>Extinction</subject><subject>Extinction, Psychological - physiology</subject><subject>Fear</subject><subject>Fear - physiology</subject><subject>Female</subject><subject>Human</subject><subject>Humans</subject><subject>Male</subject><subject>Rodent</subject><subject>Sex</subject><subject>Sex Characteristics</subject><issn>0149-7634</issn><issn>1873-7528</issn><issn>1873-7528</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkMtOwzAQRS0EoqXwCxCxYpPgZ5xskFDFS6rEAlhbjjMGV2lc7LQqf0-ilgpWrGYxZ-4dHYQuCM4IJvn1PGthVTkfYJ1RTMoMiwxTfIDGpJAslYIWh2iMCS9TmTM-QicxzjHuESaO0YgRQkvKxBhdvsAmqZ21EKA1EBPXJhZ0SGDTudZ0zren6MjqJsLZbk7Q2_3d6_QxnT0_PE1vZ6nhUnQpcIs1riooNSdcC8m11LUBS0CCLipd4QIYF5bkZSVyAtgUBS50XUqRc2rYBN1sc5eragH9ZdsF3ahlcAsdvpTXTv3dtO5Dvfu1yvOSUkH7gKtdQPCfK4idWrhooGl0C34VFaWMEiL6uh6VW9QEH2MAu68hWA2G1VztDavBsMJCDfom6Pz3l_u7H6U9cLsFoHe1dhBUNG5wW7sAplO1d_-WfANQPpHj</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Velasco, E.R.</creator><creator>Florido, A.</creator><creator>Milad, M.R.</creator><creator>Andero, R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8778-5618</orcidid></search><sort><creationdate>20190801</creationdate><title>Sex differences in fear extinction</title><author>Velasco, E.R. ; Florido, A. ; Milad, M.R. ; Andero, R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Brain - physiology</topic><topic>Extinction</topic><topic>Extinction, Psychological - physiology</topic><topic>Fear</topic><topic>Fear - physiology</topic><topic>Female</topic><topic>Human</topic><topic>Humans</topic><topic>Male</topic><topic>Rodent</topic><topic>Sex</topic><topic>Sex Characteristics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Velasco, E.R.</creatorcontrib><creatorcontrib>Florido, A.</creatorcontrib><creatorcontrib>Milad, M.R.</creatorcontrib><creatorcontrib>Andero, R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuroscience and biobehavioral reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Velasco, E.R.</au><au>Florido, A.</au><au>Milad, M.R.</au><au>Andero, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sex differences in fear extinction</atitle><jtitle>Neuroscience and biobehavioral reviews</jtitle><addtitle>Neurosci Biobehav Rev</addtitle><date>2019-08-01</date><risdate>2019</risdate><volume>103</volume><spage>81</spage><epage>108</epage><pages>81-108</pages><issn>0149-7634</issn><issn>1873-7528</issn><eissn>1873-7528</eissn><abstract>Despite the exponential increase in fear research during the last years, few studies have included female subjects in their design. The need to include females arises from the knowledge gap of mechanistic processes underlying the behavioral and neural differences observed in fear extinction. Moreover, the exact contribution of sex and hormones in relation to learning and behavior is still largely unknown. Insights from this field could be beneficial as fear-related disorders are twice as prevalent in women compared to men. Here, we review an up-to-date summary of animal and human studies in adulthood that report sex differences in fear extinction from a structural and functional approach. Furthermore, we describe how these factors could contribute to the observed sex differences in fear extinction during normal and pathological conditions.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>31129235</pmid><doi>10.1016/j.neubiorev.2019.05.020</doi><tpages>28</tpages><orcidid>https://orcid.org/0000-0002-8778-5618</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0149-7634
ispartof Neuroscience and biobehavioral reviews, 2019-08, Vol.103, p.81-108
issn 0149-7634
1873-7528
1873-7528
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6692252
source ScienceDirect Journals
subjects Animals
Brain - physiology
Extinction
Extinction, Psychological - physiology
Fear
Fear - physiology
Female
Human
Humans
Male
Rodent
Sex
Sex Characteristics
title Sex differences in fear extinction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T05%3A45%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sex%20differences%20in%20fear%20extinction&rft.jtitle=Neuroscience%20and%20biobehavioral%20reviews&rft.au=Velasco,%20E.R.&rft.date=2019-08-01&rft.volume=103&rft.spage=81&rft.epage=108&rft.pages=81-108&rft.issn=0149-7634&rft.eissn=1873-7528&rft_id=info:doi/10.1016/j.neubiorev.2019.05.020&rft_dat=%3Cproquest_pubme%3E2232115756%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c475t-e4f0a0bbe9a414a574a7adcef1e7ea8bab08e345f169b561e0c8808ad975642c3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2232115756&rft_id=info:pmid/31129235&rfr_iscdi=true