The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy in Drosophila

The notable male predominance across many human cancer types remains unexplained. Here, we show that l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differen...

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Bibliographic Details
Published in:Science advances 2019-08, Vol.5 (8), p.eaaw7965-eaaw7965
Main Authors: Molnar, Cristina, Heinen, Jan Peter, Reina, Jose, Llamazares, Salud, Palumbo, Emilio, Breschi, Alessandra, Gay, Marina, Villarreal, Laura, Vilaseca, Marta, Pollarolo, Giulia, Gonzalez, Cayetano
Format: Article
Language:English
Subjects:
Animals
Brain Neoplasms - pathology
Cancer
Drosophila melanogaster - genetics
Drosophila Proteins - genetics
Female
Gene Expression - genetics
Gene Expression Profiling
Gene Expression Regulation - genetics
Histone Code - genetics
Homeodomain Proteins - genetics
Male
Protein Kinases - genetics
SciAdv r-articles
Sex Factors
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Summary:The notable male predominance across many human cancer types remains unexplained. Here, we show that l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. By quantitative proteomics, we have identified a signature of proteins that are differentially expressed between male and female tumor samples. Prominent among them is the conserved chromatin reader PHD finger protein 7 (Phf7). We show that depletion reduces sex-dependent differences in gene expression and suppresses the enhanced malignant traits of male tumors. Our results identify potential regulators of sex-linked tumor dimorphism and show that these genes may serve as targets to suppress sex-linked malignant traits.
ISSN:2375-2548
2375-2548
DOI:10.1126/sciadv.aaw7965