Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae

Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as a...

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Published in:EXCLI journal 2019-01, Vol.18, p.445-453
Main Authors: Cherdtrakulkiat, Rungrot, Lawung, Ratana, Nabu, Sunanta, Tantimavanich, Srisurang, Sinthupoom, Nujarin, Prachayasittikul, Supaluk, Prachayasittikul, Virapong
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Language:English
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Summary:Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and antineurodegenerative activities. Herein, 8HQ (1), nitroxoline (NQ, 2) and 7-Br-8HQ (3) were investigated for antimicrobial activity against including extended spectrum β-lactamase (ESBL)-producing and carbapenemase-producing strains as well as the effect of metal ions. These compounds (1-3) displayed the great antimicrobial activity against fifty-eight bacterial isolates of and , in which NQ (2) exerted the highest antimicrobial activity with a MIC of 42.04 μM (8 µg/mL) and MBC of 168.28 μM (32 µg/mL). The MIC values of NQ (2) and 7-Br-8HQ (3) were significantly increased in the presence of Cu and Fe . This finding reveals that NQ could be an effective compound to be further developed as an antimicrobial agent for combating infections.
ISSN:1611-2156
1611-2156
DOI:10.17179/excli2019-1378