Non-professional phagocytosis: a general feature of normal tissue cells

Non-professional phagocytosis by cancer cells has been described for decades. Recently, non-professional phagocytosis by normal tissue cells has been reported, which prompted us to take a closer look at this phenomenon. Non-professional phagocytosis was studied by staining cultured cells with live-c...

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Published in:Scientific reports 2019-08, Vol.9 (1), p.11875-11875, Article 11875
Main Authors: Seeberg, Jacob C., Loibl, Monika, Moser, Fabian, Schwegler, Manuela, Büttner-Herold, Maike, Daniel, Christoph, Engel, Felix B., Hartmann, Arndt, Schlötzer-Schrehardt, Ursula, Goppelt-Struebe, Margarete, Schellerer, Vera, Naschberger, Elisabeth, Ganzleben, Ingo, Heinzerling, Lucie, Fietkau, Rainer, Distel, Luitpold V.
Format: Article
Language:English
Subjects:
13/1
13/106
13/31
13/51
14/34
14/63
631/250/1932
631/80/82/2168
Biopsy
Cancer
Cell culture
Dystrophin
Fibroblasts
Heart attacks
Humanities and Social Sciences
Immunohistochemistry
Infarction
Medical research
multidisciplinary
Paraffin
Phagocytosis
Science
Science (multidisciplinary)
Skin
Tissues
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container_title Scientific reports
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creator Seeberg, Jacob C.
Loibl, Monika
Moser, Fabian
Schwegler, Manuela
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Engel, Felix B.
Hartmann, Arndt
Schlötzer-Schrehardt, Ursula
Goppelt-Struebe, Margarete
Schellerer, Vera
Naschberger, Elisabeth
Ganzleben, Ingo
Heinzerling, Lucie
Fietkau, Rainer
Distel, Luitpold V.
description Non-professional phagocytosis by cancer cells has been described for decades. Recently, non-professional phagocytosis by normal tissue cells has been reported, which prompted us to take a closer look at this phenomenon. Non-professional phagocytosis was studied by staining cultured cells with live-cell staining dyes or by staining paraffin-embedded tissues by immunohistochemistry. Here, we report that each of 21 normal tissue cell lines from seven different organs was capable of phagocytosis, including ex vivo cell cultures examined before the 3rd passage as well as the primary and virus-transformed cell lines. We extended our analysis to an in vivo setting, and we found the occurrence of non-professional phagocytosis in healthy skin biopsies immediately after resection. Using dystrophin immunohistochemistry for membrane staining, human post-infarction myocardial tissue was assessed. We found prominent signs of non-professional phagocytosis at the transition zone of healthy and infarcted myocardia. Taken together, our findings suggest that non-professional phagocytosis is a general feature of normal tissue cells.
doi_str_mv 10.1038/s41598-019-48370-3
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subjects 13/1
13/106
13/31
13/51
14/34
14/63
631/250/1932
631/80/82/2168
Biopsy
Cancer
Cell culture
Dystrophin
Fibroblasts
Heart attacks
Humanities and Social Sciences
Immunohistochemistry
Infarction
Medical research
multidisciplinary
Paraffin
Phagocytosis
Science
Science (multidisciplinary)
Skin
Tissues
title Non-professional phagocytosis: a general feature of normal tissue cells
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