Association among resistin, adenylate cyclase-associated protein 1 and high-density lipoprotein cholesterol in patients with colorectal cancer: a multi-marker approach, as a hallmark of innovative predictive, preventive, and personalized medicine

Background Elevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma concentration, peripheral blood mononuclear cells (PBMCs) resistin messenger...

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Bibliographic Details
Published in:The EPMA journal 2019-09, Vol.10 (3), p.307-316
Main Authors: Mihajlovic, Marija, Ninic, Ana, Sopic, Miron, Miljkovic, Milica, Stefanovic, Aleksandra, Vekic, Jelena, Spasojevic-Kalimanovska, Vesna, Zeljkovic, Dejan, Trifunovic, Bratislav, Stjepanovic, Zeljka, Zeljkovic, Aleksandra
Format: Article
Language:English
Subjects:
Associations
Binding proteins
Biomedical and Life Sciences
Biomedicine
Cancer patients
Care and treatment
Cholesterol
Colorectal cancer
Diagnosis
EDTA
Enzyme-linked immunosorbent assay
Genes
Genetic polymorphisms
HDL cholesterol
Health aspects
Lipoproteins
Low density lipoproteins
Medicine/Public Health
Messenger RNA
Nucleic acids
Peptide hormones
Polymerase chain reaction
Polymorphism
Precision medicine
RNA
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Summary:Background Elevated concentrations of resistin have been reported in colorectal cancer (CRC), but its interactions with adenylate cyclase-associated protein 1 (CAP-1) are largely unexplored. We investigated resistin plasma concentration, peripheral blood mononuclear cells (PBMCs) resistin messenger ribonucleic acid (mRNA), and CAP-1 mRNA levels in CRC patients, as well as the impact of resistin gene polymorphism rs1862513 on the examined markers. We also explored associations of resistin with high-density lipoprotein cholesterol (HDL-C) and predictive potential of our parameters for CRC. Methods Eighty-six patients with CRC and 75 healthy adults were included. Commercial ELISA kit was used for obtaining resistin’s concentrations, while polymerase chain reaction (PCR) method was applied for evaluation of resistin and CAP-1 mRNA levels and rs1862513 polymorphism. Results Plasma resistin and CAP-1 mRNA levels were higher in CRC patients ( p  
ISSN:1878-5077
1878-5085
DOI:10.1007/s13167-019-00178-x