Metabolism of the Gram-Positive Bacterial Pathogen Listeria monocytogenes

Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication. Gram-positive pathogens, such as , show remarkable flexibility, which allows for exploitation of diverse biological niches from the soil to...

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Bibliographic Details
Published in:Microbiology spectrum 2019-07, Vol.7 (4)
Main Authors: Sauer, John-Demian, Herskovits, Anat A, O'Riordan, Mary X D
Format: Article
Language:English
Subjects:
Animals
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Gene Expression Regulation, Bacterial
Humans
Listeria monocytogenes
Listeria monocytogenes - genetics
Listeria monocytogenes - metabolism
Listeria monocytogenes - pathogenicity
Listeriosis
Listeriosis - microbiology
Pathogenesis
Virulence
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Summary:Bacterial metabolism represents the biochemical space that bacteria can manipulate to produce energy, reducing equivalents and building blocks for replication. Gram-positive pathogens, such as , show remarkable flexibility, which allows for exploitation of diverse biological niches from the soil to the intracytosolic space. Although the human host represents a potentially rich source for nutrient acquisition, competition for nutrients with the host and hostile host defenses can constrain bacterial metabolism by various mechanisms, including nutrient sequestration. Here, we review metabolism in the model Gram-positive bacterium, , and highlight pathways that enable the replication, survival, and virulence of this bacterial pathogen.
ISSN:2165-0497
2165-0497
DOI:10.1128/microbiolspec.GPP3-0066-2019