Genetic characterization of Echinococcus isolates from various intermediate hosts in the Qinghai-Tibetan Plateau Area, China

This study examined Echinococcus spp. genotypes and genetic variants isolated from humans as well as domestic and wild animals from the Qinghai-Tibetan Plateau Area using the cox1 gene. All samples except the pika isolates were identified as the Echinococcus granulosus sensu stricto. Sixteen differe...

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Bibliographic Details
Published in:Parasitology 2019-09, Vol.146 (10), p.1305-1312
Main Authors: Han, Xiumin, Jian, Yingna, Zhang, Xueyong, Ma, Liqing, Zhu, Wenjun, Cai, Qigang, Wu, Shile, Wang, Xiangqian, Shi, Bingqiang
Format: Article
Language:English
Subjects:
Animal populations
Animals
Animals, Domestic
Animals, Wild
Cattle
China
Cysts
Disease
Domestic animals
Echinococcosis - parasitology
Echinococcosis - veterinary
Echinococcus
Echinococcus - classification
Echinococcus - genetics
Echinococcus - isolation & purification
Electron Transport Complex IV - genetics
Epidemics
Genes
Genetic diversity
Genetic variance
Genetic Variation
Genotype
Genotype & phenotype
Genotypes
Haplotypes
Humans
Livestock
Medical ethics
Mitochondria
Mitochondrial DNA
Parasites
Patients
Population genetics
Populations
Sheep
Studies
Wild animals
Zoonoses
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Summary:This study examined Echinococcus spp. genotypes and genetic variants isolated from humans as well as domestic and wild animals from the Qinghai-Tibetan Plateau Area using the cox1 gene. All samples except the pika isolates were identified as the Echinococcus granulosus sensu stricto. Sixteen different haplotypes with considerable intraspecific variation were detected and characterized in mitochondrial cox1 sequences. The parsimonious network of cox1 haplotypes showed star-like features, and the neutrality indexes computed via Tajima's D and Fu's Fs tests showed high negative values in E. granulosus s. s., indicating deviations from neutrality; the Fst values were low among the populations, implying that the populations were not genetically differentiated. The pika isolates were identified as E. multilocularis and E. shiquicus. Only one haplotype was recognized in the pika isolates. E. granulosus s. s. was the predominant species found in animals and humans, followed by E. multilocularis and E. shiquicus, with high genetic diversity circulating among the animals and humans in this area. Further studies are needed to cover many sample collection sites and larger numbers of pathogen isolates, which may reveal abundant strains and/or other haplotypes in the hydatid cysts infecting human and animal populations of the QTPA, China.
ISSN:0031-1820
1469-8161
DOI:10.1017/S0031182019000544