Locomotion-dependent remapping of distributed cortical networks

The interactions between neocortical areas are fluid and state-dependent, but how individual neurons couple to cortex-wide network dynamics remains poorly understood. We correlated the spiking of neurons in primary visual (V1) and retrosplenial (RSP) cortex to activity across dorsal cortex, recorded...

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Bibliographic Details
Published in:Nature neuroscience 2019-05, Vol.22 (5), p.778-786
Main Authors: Clancy, Kelly B., Orsolic, Ivana, Mrsic-Flogel, Thomas D.
Format: Article
Language:English
Subjects:
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Action Potentials
Activity patterns
Analysis
Animal Genetics and Genomics
Animals
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Brain
Calcium
Calcium imaging
Cerebral Cortex - physiology
Correlation
Cortical maps
Coupling
Female
Firing pattern
Human locomotion
Locomotion
Male
Mice, Transgenic
Neural Pathways - physiology
Neurobiology
Neuroimaging
Neurons
Neurons - physiology
Neurosciences
Psychological aspects
Sensorimotor integration
Sensory neurons
Somatosensory cortex
Visual cortex
Visual Cortex - physiology
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Summary:The interactions between neocortical areas are fluid and state-dependent, but how individual neurons couple to cortex-wide network dynamics remains poorly understood. We correlated the spiking of neurons in primary visual (V1) and retrosplenial (RSP) cortex to activity across dorsal cortex, recorded simultaneously by widefield calcium imaging. Neurons were correlated with distinct and reproducible patterns of activity across the cortical surface; while some fired predominantly with their local area, others coupled to activity in distal areas. The extent of distal coupling was predicted by how strongly neurons correlated with the local network. Changes in brain state triggered by locomotion strengthened affiliations of V1 neurons with higher visual and motor areas, while strengthening distal affiliations of RSP neurons with sensory cortices. Thus, the diverse coupling of individual neurons to cortex-wide activity patterns is restructured by running in an area-specific manner, resulting in a shift in the mode of cortical processing during locomotion. Clancy et al. investigated the relationship between individual neuron activity and cortex-wide dynamics. Neurons were diversely coupled to distal areas, and locomotion affected how neurons in different areas coupled with distal activity.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-019-0357-8